The influence of androstadienone during psychosocial stress is modulated by gender, trait anxiety and subjective stress: an fMRI study

Highlights • Androstadienone (ANDR) is a synthetic steroid found in male sweat, saliva or semen. • Males, females during early follicular phase and using contraceptives were tested. • Neural stress reaction under ANDR was stronger in males than in females. • ANDR modulated stress reactions in males...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-06, Vol.68, p.126-139
Main Authors: Chung, K.C, Springer, I, Kogler, L, Turetsky, B, Freiherr, J, Derntl, B
Format: Article
Language:English
Subjects:
Adult
Androstadienes - pharmacology
Androstadienone
Anxiety - physiopathology
Anxiety Disorders - physiopathology
Brain - physiology
Brain Mapping - methods
Dorsolateral prefrontal cortex
Endocrinology & Metabolism
Female
Gender
Humans
Magnetic Resonance Imaging - methods
Male
Prefrontal Cortex - physiopathology
Psychiatry
Sex Factors
Social threat
Stress, Psychological - physiopathology
Stress, Psychological - psychology
Trait-anxiety
Young Adult
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Summary:Highlights • Androstadienone (ANDR) is a synthetic steroid found in male sweat, saliva or semen. • Males, females during early follicular phase and using contraceptives were tested. • Neural stress reaction under ANDR was stronger in males than in females. • ANDR modulated stress reactions in males depending on individual differences. • Under ANDR, DLPFC activation was negatively associated with trait-anxiety in males. • ANDR enhanced social threat, potentially facilitating adaptive stress responses.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.02.026