Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations

Increased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this increased risk remains when Amerindian anc...

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Bibliographic Details
Published in:European journal of oral sciences 2016-08, Vol.124 (4), p.406-411
Main Authors: Vieira-Machado, Camilla D., de Carvalho, Flavia M., Santana da Silva, Luiz C., dos Santos, Sidney E., Martins, Claudia, Poletta, Fernando A., Mereb, Juan C., Vieira, Alexandre R., Castilla, Eduardo E., Orioli, Iêda M.
Format: Article
Language:English
Subjects:
Brazil
Cleft Lip - genetics
cleft lip and palate
cleft palate
Cleft Palate - genetics
Dentistry
European Continental Ancestry Group - genetics
genetic ancestry
Genotype
Humans
INDEL
South American populations
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Summary:Increased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this increased risk remains when Amerindian ancestry is estimated using autosomal markers and considered in the predictive model. Ancestry was estimated through genotyping 62 insertion and deletion (INDEL) markers in sample sets of patients with CL±P, patients with cleft palate (CP), and controls, from Patagonia in southern Argentina and Belém in northern Brazil. The Amerindian ancestry in patients from Patagonia with CL±P was greater than in controls although it did not reach statistical significance. The European ancestry in patients with CL±P from Belém and in patients with CP from Belém and Patagonia was higher than in controls and statistically significant for patients with CP who were from Belém. This high contribution of European genetic ancestry among patients with CP who were from Belém has not been previously observed in American populations. Our results do not corroborate the currently accepted risks for CL±P and CP estimated by epidemiological studies in the North American populations and probably reflect the higher admixture found in South American ethnic groups when compared with the same ethnic groups from the North American populations.
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12275