Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function

CD4(+) germinal center (GC)-T follicular helper (Tfh) cells help B cells become long-lived plasma cells and memory cells. The transcriptional repressor Bcl6 plays a key role in GC-Tfh formation by inhibiting the expression of genes that promote differentiation into other lineages. We determined whet...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2015-06, Vol.194 (12), p.5604-5608
Main Authors: Yang, Jessica A, Tubo, Noah J, Gearhart, Micah D, Bardwell, Vivian J, Jenkins, Marc K
Format: Article
Language:English
Subjects:
Animals
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Cell Differentiation - genetics
Cell Differentiation - immunology
Female
Germinal Center - immunology
Germinal Center - metabolism
Immunophenotyping
Listeria monocytogenes
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Male
Mice
Mice, Transgenic
Phenotype
Repressor Proteins - deficiency
Repressor Proteins - genetics
Repressor Proteins - metabolism
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:CD4(+) germinal center (GC)-T follicular helper (Tfh) cells help B cells become long-lived plasma cells and memory cells. The transcriptional repressor Bcl6 plays a key role in GC-Tfh formation by inhibiting the expression of genes that promote differentiation into other lineages. We determined whether BCOR, a component of a Polycomb repressive complex that interacts with the Bcl6 BTB domain, influences GC-Tfh differentiation. T cell-targeted BCOR deficiency led to a substantial loss of peptide:MHC class II-specific GC-Tfh cells following Listeria monocytogenes infection and a 2-fold decrease following immunization with a peptide in CFA. The reduction in GC-Tfh cells was associated with diminished plasma cell and GC B cell formation. Thus, T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1500201