Increased microcirculation detected by dynamic contrast‐enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma

Summary This prospective study aimed to investigate the prognostic significance of dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) as a non‐invasive imaging technique delivering the quantitative parameters amplitude A (reflecting blood volume) and exchange rate constant kep (reflectin...

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Published in:British journal of haematology 2016-07, Vol.174 (1), p.127-135
Main Authors: Hillengass, Jens, Ritsch, Judith, Merz, Maximilian, Wagner, Barbara, Kunz, Christina, Hielscher, Thomas, Laue, Hendrik, Bäuerle, Tobias, Zechmann, Christian M., Ho, Anthony D., Schlemmer, Heinz‐Peter, Goldschmidt, Hartmut, Moehler, Thomas M., Delorme, Stefan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bone Marrow - blood supply
Bone Marrow - diagnostic imaging
Bone Marrow - pathology
Case-Control Studies
Disease Progression
dynamic contrast‐enhanced magnetic resonance imaging
Female
Humans
Lumbar Vertebrae - blood supply
Lumbar Vertebrae - diagnostic imaging
Magnetic Resonance Imaging - methods
Male
Microcirculation
Middle Aged
monoclonal gammopathy of undetermined significance
Monoclonal Gammopathy of Undetermined Significance - diagnostic imaging
Monoclonal Gammopathy of Undetermined Significance - pathology
Multiple Myeloma - blood supply
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - pathology
Prognosis
Prospective Studies
risk factor
Smouldering multiple myeloma
Young Adult
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Summary:Summary This prospective study aimed to investigate the prognostic significance of dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) as a non‐invasive imaging technique delivering the quantitative parameters amplitude A (reflecting blood volume) and exchange rate constant kep (reflecting vascular permeability) in patients with asymptomatic monoclonal plasma cell diseases. We analysed DCE‐MRI parameters in 33 healthy controls and 148 patients with monoclonal gammopathy of undetermined significance (MGUS) or smouldering multiple myeloma (SMM) according to the 2003 IMWG guidelines. All individuals underwent standardized DCE‐MRI of the lumbar spine. Regions of interest were drawn manually on T1‐weighted images encompassing the bone marrow of each of the 5 lumbar vertebrae sparing the vertebral vessel. Prognostic significance for median of amplitude A (univariate: P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.14038