The feet in systemic lupus erythematosus; are we underestimating their involvement and functional impact?

To evaluate biomechanical and ultrasound (US) abnormalities in SLE patients as compared with controls and to assess the relationship between these abnormalities and SLE activity. Fifty-four consecutive female patients with SLE with and without foot pain and 60 female controls (30 with foot pain and...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2016-07, Vol.34 (4), p.609-617
Main Authors: Morales-Lozano, Rosario, Martínez-Barrio, Julia, González-Fernández, María Luz, López-Longo, Francisco Javier, Ovalles-Bonilla, Juan Gabriel, Valor, Lara, Janta, Iustina, Nieto, Juan Carlos, Hernández-Flórez, Diana, González, Carlos M, Monteagudo, Indalecio, Garrido, Jesús, Carreño, Luis, Naredo, Esperanza
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Biomarkers - blood
Biomechanical Phenomena
Case-Control Studies
Cross-Sectional Studies
Female
Foot - diagnostic imaging
Foot - physiopathology
Foot Deformities, Acquired - blood
Foot Deformities, Acquired - diagnostic imaging
Foot Deformities, Acquired - etiology
Foot Deformities, Acquired - physiopathology
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Pain - blood
Pain - diagnostic imaging
Pain - etiology
Pain - physiopathology
Pain Measurement
Podiatry - methods
Predictive Value of Tests
Prognosis
Prospective Studies
Severity of Illness Index
Ultrasonography, Doppler
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Summary:To evaluate biomechanical and ultrasound (US) abnormalities in SLE patients as compared with controls and to assess the relationship between these abnormalities and SLE activity. Fifty-four consecutive female patients with SLE with and without foot pain and 60 female controls (30 with foot pain and 30 without foot pain) were recruited. SLE activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). SLE patients and controls blindly underwent a comprehensive podiatric, biomechanical and US evaluation of the feet. US assessment included detection of B-mode synovitis, tenosynovitis, enthesopathy, bone changes and synovial, tenosynovial and entheseal power Doppler (PD) signal. Thirty-one (57.4%) SLE patients had bilateral foot pain and 5 (9.3%) had unilateral foot pain. Metatarsalgia was the most common location for pain but without significant difference between groups (p=0.284). Toe joint deformities were significantly more common in SLE feet as compared with control feet (p
ISSN:0392-856X
1593-098X