Lissencephaly in an adult Australian Kelpie

CASE REPORT: A 6‐year‐old neutered male Australian Kelpie presented with a 2‐year history of seizures. Neurological examination was consistent with a generalised prosencephalic lesion. Serum biochemical testing was performed in addition to magnetic resonance imaging of the brain and cerebrospinal fl...

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Bibliographic Details
Published in:Australian veterinary journal 2016-04, Vol.94 (4), p.107-110
Main Authors: Fraser, AR, le Chevoir, MA, Long, SN
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - therapeutic use
Cerebral Cortex - pathology
Convulsions & seizures
Dog Diseases - drug therapy
Dog Diseases - etiology
Dog Diseases - pathology
Dogs
lissencephaly
Lissencephaly - complications
Lissencephaly - drug therapy
Lissencephaly - pathology
Lissencephaly - veterinary
Magnetic Resonance Imaging - veterinary
Male
neuronal migration disorder
NMR
Nuclear magnetic resonance
Phenobarbital - therapeutic use
Plant Preparations - therapeutic use
seizures
Seizures - drug therapy
Seizures - etiology
Seizures - veterinary
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Summary:CASE REPORT: A 6‐year‐old neutered male Australian Kelpie presented with a 2‐year history of seizures. Neurological examination was consistent with a generalised prosencephalic lesion. Serum biochemical testing was performed in addition to magnetic resonance imaging of the brain and cerebrospinal fluid analysis. Magnetic resonance imaging revealed a reduction in the number of sulci and gyri in addition to cortical thickening, resulting in a diagnosis of lissencephaly. The dog was treated with anticonvulsants and follow‐up information obtained from the referring veterinarian 11 months after diagnosis indicated that the dog had good seizure control. CONCLUSION: This is the first report of lissencephaly in the Australian Kelpie and would suggest that some dogs with the condition can be managed with long‐term anticonvulsant medication.
ISSN:0005-0423
1751-0813
DOI:10.1111/avj.12423