FDG-PET characteristics of Hürthle cell and follicular adenomas

Objective Follicular (FN) and Hürthle cell neoplasms (HCN) are considered indeterminate on thyroid fine needle aspiration cytology and are preoperative diagnostic challenges. The role of [ 18 F]-2-fluoro-2-deoxy- d -glucose (FDG) in characterizing indeterminate thyroid nodules remains equivocal, bec...

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Bibliographic Details
Published in:Annals of nuclear medicine 2016-08, Vol.30 (7), p.506-509
Main Authors: Pathak, Kumar Alok, Klonisch, Thomas, Nason, Richard W., Leslie, William D.
Format: Article
Language:English
Subjects:
Adenoma - diagnostic imaging
Adenoma - metabolism
Adenoma - pathology
Age
Benign
Biological Transport
Computed tomography
Cytology
Diagnosis
Diagnostic systems
Differential diagnosis
Discrimination
Emission analysis
False Positive Reactions
Female
Females
Gender
Glucose
Histopathology
Humans
Imaging
Male
Mediastinum
Medicine
Medicine & Public Health
Middle Aged
Neck
Neoplasms
Nodules
Nuclear Medicine
Optimization
Oxyphil Cells - pathology
Pathology
Patients
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography
Radiology
Sensitivity
Sensitivity and Specificity
Short Communication
Thyroid
Thyroid gland
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Tomography
Tumors
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Summary:Objective Follicular (FN) and Hürthle cell neoplasms (HCN) are considered indeterminate on thyroid fine needle aspiration cytology and are preoperative diagnostic challenges. The role of [ 18 F]-2-fluoro-2-deoxy- d -glucose (FDG) in characterizing indeterminate thyroid nodules remains equivocal, because of the increased FDG uptake by some benign thyroid nodules. The objective of this study was to compare the FDG positron emission tomography/computerized tomography (PET/CT) characteristics of follicular (FA) and Hürthle cell adenomas (HCA). Methods Twenty-nine patients with 31 thyroid nodules underwent FDG-PET/CT scans of the neck and superior mediastinum for indeterminate FN/HCN, and were later found to have benign adenomas on final histopathology. All scans were reported by a single observer, who was blinded to the surgical and pathology findings. Receiver operating characteristic (ROC) curve analysis of maximum standardized uptake value (SUV max ) and the area under the curve (AUROC) were used to assess discrimination between FA and HCA. Youden index was used to identify the optimal cut-off SUV max . Sensitivity, specificity, predictive values and overall accuracy were used as measures of performance. Results The mean age of our study cohort was 60.7 ± 12.6 years and 77 % of the patients were females. Age of the patients ( p  = 0.48), their gender ( p  = 0.52), and the size of thyroid nodules ( p  = 0.79) were similar for FA and HCA. Increased focal FDG uptake was observed in 100 % of HCA and 52 % of FA ( p  = 0.02). SUV max of HCA was significantly higher ( p  
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-016-1087-6