The Charlson comorbidity index is a prognostic factor in sinonasal tract squamous cell carcinoma

High Charlson comorbidity index values have been reported to be associated with shorter overall survival in various types of cancer. We investigated whether Charlson comorbidity index values were correlated with overall survival in patients with resectable sinonasal tract squamous cell carcinoma. Se...

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Published in:Japanese journal of clinical oncology 2016-07, Vol.46 (7), p.646-651
Main Authors: Suzuki, Hidenori, Hanai, Nobuhiro, Nishikawa, Daisuke, Fukuda, Yujiro, Koide, Yusuke, Kodaira, Takeshi, Tachibana, Hiroyuki, Tomita, Natsuo, Makita, Chiyoko, Hasegawa, Yasuhisa
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - epidemiology
Comorbidity
Female
Head and Neck Neoplasms - epidemiology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Paranasal Sinus Neoplasms - epidemiology
Prognosis
Proportional Hazards Models
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
Survival Rate
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Summary:High Charlson comorbidity index values have been reported to be associated with shorter overall survival in various types of cancer. We investigated whether Charlson comorbidity index values were correlated with overall survival in patients with resectable sinonasal tract squamous cell carcinoma. Seventy-nine patients with resectable sinonasal tract squamous cell carcinoma were treated with curative intent. The Charlson comorbidity index values were calculated by the summation of the weight scores of 19 medical conditions (other than sinonasal tract squamous cell carcinoma) before treatment. The survival rate was analyzed according to the Kaplan-Meier method. Univariate and multivariate survival analyses were performed using the Wilcoxon test and the Cox proportional hazards model, respectively. According to a univariate analysis, a Charlson comorbidity index value ≥6 was found to be significantly correlated with shorter overall survival (P
ISSN:0368-2811
1465-3621
DOI:10.1093/jjco/hyw049