Assessment of metastatic risk of gastric GIST based on treatment-naïve CT features

Abstract Objective To study whether the CT features of treatment-naïve gastric GIST may be used to assess metastatic risk. Methods In this IRB approved retrospective study, with informed consent waived, contrast enhanced CT images of 143 patients with pathologically confirmed treatment-naïve gastric...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2016-08, Vol.42 (8), p.1222-1228
Main Authors: O'Neill, A.C, Shinagare, A.B, Kurra, V, Tirumani, S.H, Jagannathan, J.P, Baheti, A.D, Hornick, J.L, George, S, Ramaiya, N.H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Cytoreduction Surgical Procedures
Female
Gastrectomy
Gastrointestinal stromal tumor
Gastrointestinal Stromal Tumors - diagnostic imaging
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - secondary
Gastrointestinal Stromal Tumors - therapy
Hematology, Oncology and Palliative Medicine
Humans
Male
Metastasis
Middle Aged
Multivariate Analysis
Neoadjuvant Therapy
Neoplasm Metastasis
Protein Kinase Inhibitors - therapeutic use
Retrospective Studies
Risk Assessment
Risk stratification
Stomach
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
Surgery
Tomography, X-Ray Computed
Tumor Burden
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective To study whether the CT features of treatment-naïve gastric GIST may be used to assess metastatic risk. Methods In this IRB approved retrospective study, with informed consent waived, contrast enhanced CT images of 143 patients with pathologically confirmed treatment-naïve gastric GIST (74 men, 69 women; mean age 61 years, SD ± 14) were reviewed in consensus by two oncoradiologists blinded to clinicopathologic features and clinical outcome and morphologic features were recorded. The metastatic spread was recorded using available imaging studies and electronic medical records (median follow up 40 months, interquartile range, IQR, 21–61). The association of maximum size in any plane (≤10 cm or >10 cm), outline (smooth or irregular/lobulated), cystic areas (≤50% or >50%), exophytic component (≤50% or >50%), and enhancing solid component (present or absent) with metastatic disease were analyzed using univariate (Fisher's exact test) and multivariate (logistic regression) analysis. Results Metastatic disease developed in 42 (29%) patients (28 at presentation, 14 during follow-up); 23 (16%) patients died. On multivariate analysis, tumor size >10 cm (p = 0.0001, OR 9.9), irregular/lobulated outline (p = 0.001, OR 5.6) and presence of a enhancing solid component (p 5–≤10 cm (p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2016.03.032