Microcystin-LR promote intestinal secretion of water and electrolytes in rats
We showed previously that exposure to microcystin-LR causes renal toxic effects in isolated perfused rat kidney, and that inflammatory mediators from supernatants of macrophages stimulated by microcystin-LR are involved in this process. The aim of this research was to examine water and electrolytes...
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Published in: | Toxicon (Oxford) 2004-10, Vol.44 (5), p.555-559 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | We showed previously that exposure to microcystin-LR causes renal toxic effects in isolated perfused rat kidney, and that inflammatory mediators from supernatants of macrophages stimulated by microcystin-LR are involved in this process. The aim of this research was to examine water and electrolytes secretion in vivo, induced by microcystin-LR and supernatant of macrophages stimulated for this toxin (SUP.MϕS+MCLR), using perfused rat ileal segment and ligated intestinal loop models. We found microcystin-LR at 1
μg/ml (0.09±0.003* vs. control 0.07±0.001
g of secretion/2
cm of loop;
P |
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ISSN: | 0041-0101 1879-3150 |