Microcystin-LR promote intestinal secretion of water and electrolytes in rats

We showed previously that exposure to microcystin-LR causes renal toxic effects in isolated perfused rat kidney, and that inflammatory mediators from supernatants of macrophages stimulated by microcystin-LR are involved in this process. The aim of this research was to examine water and electrolytes...

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Published in:Toxicon (Oxford) 2004-10, Vol.44 (5), p.555-559
Main Authors: Nobre, A.C.L., Nunes-Monteiro, S.M., Monteiro, M.C.S.A., Martins, A.M.C., Havt, A., Barbosa, P.S.F., Lima, A.A.M., Monteiro, H.S.A.
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Language:eng
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Summary:We showed previously that exposure to microcystin-LR causes renal toxic effects in isolated perfused rat kidney, and that inflammatory mediators from supernatants of macrophages stimulated by microcystin-LR are involved in this process. The aim of this research was to examine water and electrolytes secretion in vivo, induced by microcystin-LR and supernatant of macrophages stimulated for this toxin (SUP.MϕS+MCLR), using perfused rat ileal segment and ligated intestinal loop models. We found microcystin-LR at 1 μg/ml (0.09±0.003* vs. control 0.07±0.001 g of secretion/2 cm of loop; P
ISSN:0041-0101
1879-3150