Flavonoids, the emerging dietary supplement against cisplatin-induced nephrotoxicity

The letter illustrates the emerging potential of flavonoids as dietary supplement to ameliorate cisplatin-induced nephrotoxicity and refers to the recent article on ‘‘Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat’’ by Chtourou et al. They demon...

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Bibliographic Details
Published in:Chemico-biological interactions 2016-03, Vol.248, p.18-20
Main Authors: K.V., Athira, Madhana, Rajaram Mohanrao, Lahkar, Mangala
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antineoplastic Agents - adverse effects
Antioxidants - therapeutic use
Cancer
Cisplatin
Cisplatin - adverse effects
Citrus
Flavanones - therapeutic use
Flavonoids
Kidney - drug effects
Kidney Diseases - chemically induced
Nephrotoxicity
Vitaceae
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Summary:The letter illustrates the emerging potential of flavonoids as dietary supplement to ameliorate cisplatin-induced nephrotoxicity and refers to the recent article on ‘‘Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat’’ by Chtourou et al. They demonstrated that supplementation of naringin, a flavanone glycoside, found in grape and citrus fruit species, can attenuate cisplatin-induced renal dysfunction via restoration of redox balance and suppression of inflammation, NF-κB activation and apoptosis. The chemotherapeutic efficacy of cisplatin has always compelled the researchers to find solution to ameliorate its side effects. In recent years, numerous candidates have been evaluated for their protective potential against cisplatin-induced nephrotoxicity and flavonoids have come up with promising results. The future prospects might be promising with a proper refinement and collective integration of the preclinical and clinical research in the field of flavonoid supplementation to cisplatin therapy. •Cisplatin is a widely used and highly effective chemotherapeutic agent.•Nephrotoxicity is a major concern in patients receiving cisplatin therapy.•Flavonoids exhibit significant protection against cisplatin-induced renal damage.•A well-defined elaborate research on flavonoids might offer a successful strategy.
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2016.02.005