Neural basis of reward anticipation and its genetic determinants

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (14), p.3879-3884
Main Authors: Jia, Tianye, Macare, Christine, Desrivières, Sylvane, Gonzalez, Dante A., Tao, Chenyang, Ji, Xiaoxi, Ruggeri, Barbara, Nees, Frauke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Conrod, Patricia J., Dove, Rachel, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lemaitre, Hervé, Martinot, Jean-Luc, Paus, Tomáš, Pausova, Zdenka, Poline, Jean-Baptiste, Rietschel, Marcella, Robbins, Trevor, Smolka, Michael N., Müller, Christian P., Feng, Jianfeng, Rothenfluh, Adrian, Flor, Herta, Schumann, Gunter
Format: Article
Language:English
Subjects:
Addictions
Adolescent
Alcohol Drinking - psychology
Alcohol use
Animals
Anticipation, Psychological - physiology
ATPases Associated with Diverse Cellular Activities
Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention Deficit Hyperactivity Disorder
Biological Sciences
Brain
Brain Mapping
Child
Corpus Striatum - physiopathology
Drosophila
Endosomal Sorting Complexes Required for Transport - genetics
Female
Forecasting
Genome-Wide Association Study
Haplotypes - genetics
Humans
Insects
Male
Mental disorders
Motivation
Neuropsychological Tests
Reward
Teenagers
Vacuolar Proton-Translocating ATPases - genetics
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Summary:Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1503252113