Atrial Natriuretic Peptide Inhibits Spontaneous Contractile Activity of Lymph Nodes

Atrial natriuretic peptide dose-dependently inhibited spontaneous phase and tonic activity of smooth muscle strips from the capsule of isolated bovine mesenteric lymph nodes. Pretreatment with L-NAME, diclofenac, and methylene blue had practically no effect on the peptide-induced relaxation response...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-06, Vol.161 (2), p.221-223
Main Authors: Lobov, G. I., Pan’kova, M. N.
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - pharmacology
Atrial Natriuretic Factor - physiology
Biomedical and Life Sciences
Biomedicine
Cattle
Cell Biology
Glyburide
Internal Medicine
Laboratory Medicine
Lymph Nodes - physiology
Muscle Contraction
Muscle, Smooth
Natriuretic peptides
Pathology
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Summary:Atrial natriuretic peptide dose-dependently inhibited spontaneous phase and tonic activity of smooth muscle strips from the capsule of isolated bovine mesenteric lymph nodes. Pretreatment with L-NAME, diclofenac, and methylene blue had practically no effect on the peptide-induced relaxation responses. In contrast, glibenclamide significantly reduced the inhibitory effect of atrial natriuretic peptide. We suppose that the NO-dependent and cyclooxygenase signaling pathways are not involved in implementation of the inhibitory effects of atrial natriuretic peptide. ATP-sensitive K + -channels of the smooth muscle cell membrane are the last component in the signaling pathway leading to relaxation of smooth muscles of the lymph node capsule caused by atrial natriuretic peptide; activation of these channels leads to membrane hyperpolarization and smooth muscle relaxation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3380-8