Enhancement of Curcumin Solubility by Phase Change from Crystalline to Amorphous in Cur-TPGS Nanosuspension

Nanosuspensions (NSs) were fabricated to enhance water solubility, dissolution rate, and oral adsorption of water insoluble curcumin using sonoprecipitation method. As a good stabilizer, d‐α‐Tocopherol polyethylene glycol 1000 succinate (TPGS) was used to improve the stability of curcumin‐TPGS NSs (...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food science 2016-02, Vol.81 (2), p.N494-N501
Main Authors: Shin, Gye Hwa, Li, Jinglei, Cho, Jin Hun, Kim, Jun Tae, Park, Hyun Jin
Format: Article
Language:English
Subjects:
Adsorption
alpha-Tocopherol - chemistry
Chemistry, Pharmaceutical - methods
Crystal structure
Crystallization
Curcuma - chemistry
curcumin
Curcumin - chemistry
Dietary supplements
Dissolution
Drug Stability
Food science
Homogenizing
Nanostructure
nanosuspensions
Nanotechnology
Particle Size
Phase change
Polyethylene Glycols - chemistry
Powders
Solubility
TPGS
ultrasonic homogenization
Vitamin E - analogs & derivatives
Vitamin E - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanosuspensions (NSs) were fabricated to enhance water solubility, dissolution rate, and oral adsorption of water insoluble curcumin using sonoprecipitation method. As a good stabilizer, d‐α‐Tocopherol polyethylene glycol 1000 succinate (TPGS) was used to improve the stability of curcumin‐TPGS NSs (Cur‐TPGS NSs). Ultrasonic homogenization (UH) could effectively enhance the solubility of curcumin and to produce homogeneous NSs with small particle sizes. Water solubility of curcumin was significantly improved from 0.6 μg/mL in pure water to 260 μg/mL in the mixture of curcumin and TPGS (1:10) with UH treatment. The mean particle size of Cur‐TPGS NSs was decreased significantly after UH and maintained between 208 and 246 nm. Lyophilized powder of Cur‐TPGS NSs was dissolved about 91.08% whereas the pristine curcumin powder was dissolved only 6.5% at pH 7.4. This study showed a great potential of Cur‐TPGS NSs as a good nano‐formulation of curcumin with enhanced solubility and improved oral adsorption.
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.13208