Toward accelerated bone regeneration by altering poly(d,l-lactic-co-glycolic) acid porogen content in calcium phosphate cement

This work aimed to compare in vitro degradation of dense PLGA microspheres and milled PLGA particles as porogens within CPC, considering that the manufacturing of milled PLGA is more cost‐effective when compared with PLGA microspheres. Additionally, we aimed to examine the effect of porogen amount w...

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Published in:Journal of biomedical materials research. Part A 2016-02, Vol.104 (2), p.483-492
Main Authors: van Houdt, C. I. A., Preethanath, R. S., van Oirschot, B. A. J. A., Zwarts, P. H. W., Ulrich, D. J. O., Anil, S., Jansen, J. A., van den Beucken, J. J. J. P.
Format: Article
Language:English
Subjects:
Animals
Bone Cements - chemistry
Bone Cements - pharmacology
bone regeneration
Bone Regeneration - drug effects
bone substitute
Bones
Calcium phosphate
calcium phosphate cement
Calcium Phosphates - chemistry
Calcium Phosphates - pharmacology
Degradation
Femur - injuries
Femur - metabolism
Femur - pathology
Formations
In vitro testing
l-lactic-co-glycolic) acid
Lactic Acid - chemistry
Lactic Acid - pharmacology
Male
material degradation
Microspheres
Osteogenesis - drug effects
poly(d
poly(d,l‐lactic‐co‐glycolic) acid
Polyglycolic Acid - chemistry
Polyglycolic Acid - pharmacology
Porosity
Rats
Rats, Wistar
Surgical implants
Tuning
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Summary:This work aimed to compare in vitro degradation of dense PLGA microspheres and milled PLGA particles as porogens within CPC, considering that the manufacturing of milled PLGA is more cost‐effective when compared with PLGA microspheres. Additionally, we aimed to examine the effect of porogen amount within CPC/PLGA on degradation and bone formation. Our in vitro results showed no differences between both forms of PLGA particles (as porogens in CPC; spherical for microspheres, irregular for milled) regarding morphology, porosity, and degradation. Using milled PLGA as porogens within CPC/PLGA, we evaluated the effect of porogen amount on degradation and bone forming capacity in vivo. Titanium landmarks surrounded by CPC/PLGA with 30 and 50 wt % PLGA, were implanted in forty femoral bone defects of twenty male Wistar rats. Histomorphometrical results showed a significant temporal decrease in the amount of CPC, for both formulas, and confirmed that 50 wt % PLGA degrades faster than 30 wt%, and allows for a 1.5‐fold higher amount of newly formed bone. Taken together, this study demonstrated that (i) milled PLGA particles perform equal to PLGA microspheres, and (ii) tuning of the PLGA content in CPC/PLGA is a feasible approach to leverage material degradation and bone formation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 483–492, 2016.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.35584