Transferrin-Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto-Dendritic Nanosystem

A multicomponent magneto‐dendritic nanosystem (MDNS) is designed for rapid tumor cell targeting, isolation, and high‐resolution imaging by a facile bioconjugation approach. The highly efficient and rapid‐acting MDNS provides a convenient platform for simultaneous isolation and high‐resolution imagin...

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Bibliographic Details
Published in:Advanced healthcare materials 2013-06, Vol.2 (6), p.800-805
Main Authors: Banerjee, Shashwat S., Jalota-Badhwar, Archana, Satavalekar, Sneha D., Bhansali, Sujit G., Aher, Naval D., Mascarenhas, Russel R., Paul, Debjani, Sharma, Somesh, Khandare, Jayant J.
Format: Article
Language:English
Subjects:
bioimaging
Cancer
cancer diagnostics
Cell Separation - methods
Circulating
dendrimer
Diagnosis
Health care
Hep G2 Cells
Humans
Imaging
Immunomagnetic Separation - instrumentation
Immunomagnetic Separation - methods
magnetic materials
Medical imaging
Molecular Diagnostic Techniques - instrumentation
Molecular Diagnostic Techniques - methods
multicomponent nanosystem
Nanoparticles - chemistry
Nanostructure
Neoplastic Cells, Circulating - metabolism
Neoplastic Cells, Circulating - pathology
Platforms
Transferrin
Transferrin - pharmacokinetics
tumor cell isolation
Tumor cells
Tumors
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Summary:A multicomponent magneto‐dendritic nanosystem (MDNS) is designed for rapid tumor cell targeting, isolation, and high‐resolution imaging by a facile bioconjugation approach. The highly efficient and rapid‐acting MDNS provides a convenient platform for simultaneous isolation and high‐resolution imaging of tumor cells, potentially leading towards an early diagnosis of cancer.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200164