Mussel-Inspired Coating of Polydopamine Directs Endothelial and Smooth Muscle Cell Fate for Re-endothelialization of Vascular Devices

Polydopamine (PDAM), a mussel adhesive protein inspired coating that can be easily deposited onto a wide range of metallic, inorganic, and organic materials, gains interest also in the field of biomaterials. In this work, PDAM is applied as coating on 316L stainless steel (SS) stents and the respons...

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Bibliographic Details
Published in:Advanced healthcare materials 2012-09, Vol.1 (5), p.548-559
Main Authors: Yang, Zhilu, Tu, Qiufen, Zhu, Ying, Luo, Rifang, Li, Xin, Xie, Yichu, Maitz, Manfred F., Wang, Jin, Huang, Nan
Format: Article
Language:English
Subjects:
Adhesion
Animals
Arteries
Austenitic stainless steels
Biomaterials
Biomimetic Materials - chemistry
Bivalvia - chemistry
Blood Vessel Prosthesis
Cell Adhesion - physiology
Cell Proliferation
Cell Survival - physiology
Cells, Cultured
Coated Materials, Biocompatible - chemistry
Coating
endothelial cells
Endothelial Cells - cytology
Endothelial Cells - physiology
Heat resistant steels
hemocompatibility
Humans
Indoles - chemistry
Materials Testing
Muscles
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - physiology
polydopamine
Polymers - chemistry
Smooth muscle
smooth muscle cells
Stents
Surgical implants
Veins
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Summary:Polydopamine (PDAM), a mussel adhesive protein inspired coating that can be easily deposited onto a wide range of metallic, inorganic, and organic materials, gains interest also in the field of biomaterials. In this work, PDAM is applied as coating on 316L stainless steel (SS) stents and the response of cells of the blood vessel wall, human umbilical vein endothelial cell (HUVEC), and human umbilical artery smooth muscle cell (HUASMC) as predictors for re‐endothelialization is tested. It is found that the PDAM‐modified surface significantly enhances HUVEC adhesion, proliferation, and migration, release of nitric oxide (NO), and secretion of prostaglandin I2 (PGI2). Additionally, the PDAM‐modified surface shows a remarkable ability to decrease the adhesion and proliferation of HUASMCs. As a blood‐contacting material, the PDAM tends to improve the hemocompatibility compared with the substrate 316L SS. It is noteworthy that the PDAM coating shows good resistance to the deformation behavior of compression and expansion of a stent. These data suggest the potential of PDAM as a blood‐contacting material for the application in vascular stents or grafts. A durable, mussel‐inspired, polydopamine‐coated stent is reported. This mussel‐inspired coated stent shows significant enhancement in human umbilical vein endothelial cell (HUVEC) attachment, proliferation, migration, and function as compared with the bare 316L SS stent. The mussel‐inspired coated stent also has the substantial ability to inhibit human umbilical artery smooth muscle cell (HUASMC) adhesion and proliferation, suggesting it has the potential to address issues associated with re‐endothelialization and restenosis.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200073