A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing

In order to prepare a novel hemostatic dressing for uncontrolled hemorrhage, a porous chitosan sponge was coated with self-assembled（thrombin/tannic acid）n films, which were based on hydrogen bonding interactions between thrombin and tannic acid at physiologic p H. According to the whole blood clott...

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Bibliographic Details
Published in:Chinese journal of polymer science 2015-02, Vol.33 (2), p.284-290
Main Authors: Huang, Xiao-fei, Jia, Jing-wei, Wang, Zheng-ke, Hu, Qiao-ling
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Clotting
Coating
Condensed Matter Physics
Dressing
Hemostatics
Industrial Chemistry/Chemical Engineering
Polymer Sciences
Sponges
Tannic acid
Thrombin
凝血酶
单宁酸
壳聚糖
多层膜
敷料
止血
海绵
自组装
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Summary:In order to prepare a novel hemostatic dressing for uncontrolled hemorrhage, a porous chitosan sponge was coated with self-assembled（thrombin/tannic acid）n films, which were based on hydrogen bonding interactions between thrombin and tannic acid at physiologic p H. According to the whole blood clotting test, the coated chitosan sponges showed a significantly high rate of blood clotting due to the addition of thrombin. On the other hand, the storable half-life of immobilized thrombin is extended to 66.9 days at room temperature, which is 8.5 times longer than unfixed thrombin. It is because of the immobilization effect of, not only the porous structure of chitosan sponge but also the interactions between thrombin and tannic acid. In addition, the tannic acid has similar antibacterial effect to chitosan. Therefore, it is an excellent combination of chitosan, thrombin and tannic acid. Besides, all of materials in this research have been approved by the United States Food and Drug Administration（FDA）. So the chitosan-based sponge is a promising candidate dressing for uncontrolled hemorrhage due to its storable, bio-safe and highly effective hemostatic properties.
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-015-1580-8