An Organic Field-effect Transistor with an Extended-gate Electrode Capable of Detecting Human Immunoglobulin A

We herein report on the development of an extended-gate type organic field-effect transistor (OFET)-based immunosensor for the detection of human immunoglobulin A (IgA). The titration results of IgA exhibited shifts in the transfer characteristics of the OFET sensor device with increasing IgA concen...

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Bibliographic Details
Published in:Analytical Sciences 2015/07/10, Vol.31(7), pp.725-728
Main Authors: MINAMIKI, Tsukuru, MINAMI, Tsuyoshi, SASAKI, Yui, KURITA, Ryoji, NIWA, Osamu, WAKIDA, Shin-ichi, TOKITO, Shizuo
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biosensing Techniques - instrumentation
Chemistry
Electrochemistry
Electrodes
Field effect transistors
Human
Humans
Immunoassay
immunoglobulin A
Immunoglobulin A - analysis
Immunoglobulin A - chemistry
Immunoglobulins
immunosensor
Immunosensors
label-free
Limit of Detection
Mathematical analysis
Monitoring
Organic Chemicals - chemistry
Organic field-effect transistor
self-assembled monolayer
Semiconductor devices
Transistors, Electronic
Water - chemistry
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Summary:We herein report on the development of an extended-gate type organic field-effect transistor (OFET)-based immunosensor for the detection of human immunoglobulin A (IgA). The titration results of IgA exhibited shifts in the transfer characteristics of the OFET sensor device with increasing IgA concentration. A linear detection range from 0 to 10 μg/mL was realized with a detection limit of 2.1 μg/mL, indicating that the OFET-based immunosensor can be potentially applied to the monitoring of infectious diseases and psychological stress in daily life.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.31.725