α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study

The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin (βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its mechanism of action through docking study for a possible interaction with receptors. The αTPN-βCD complex was prepared and c...

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Bibliographic Details
Published in:Chemico-biological interactions 2016-07, Vol.254, p.54-62
Main Authors: Oliveira, Makson G.B., Brito, Renan G., Santos, Priscila L., Araújo-Filho, Heitor G., Quintans, Jullyana S.S., Menezes, Paula P., Serafini, Mairim R., Carvalho, Yasmim M.B.G., Silva, Juliane C., Almeida, Jackson R.G.S., Scotti, Luciana, Scotti, Marcus T., Shanmugam, Saravanan, Thangaraj, Parimelazhagan, Araújo, Adriano A.S., Quintans-Júnior, Lucindo J.
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Behavior, Animal - drug effects
beta-Cyclodextrins - chemistry
Binding Sites
Chronic pain
Cyclohexenes - chemistry
Cyclohexenes - pharmacology
Cyclohexenes - therapeutic use
Disease Models, Animal
Fibromyalgia
Fibromyalgia - drug therapy
Fibromyalgia - metabolism
Fibromyalgia - pathology
Hyperalgesia - chemically induced
Hyperalgesia - drug therapy
Hyperalgesia - pathology
Male
Mice
Molecular Docking Simulation
Monoterpenes - chemistry
Monoterpenes - pharmacology
Monoterpenes - therapeutic use
Naloxone - pharmacology
Ondansetron - pharmacology
Opioid
Pain
Protein Structure, Tertiary
Receptors, Opioid, delta - chemistry
Receptors, Opioid, delta - metabolism
Receptors, Opioid, kappa - chemistry
Receptors, Opioid, kappa - metabolism
Receptors, Opioid, mu - chemistry
Receptors, Opioid, mu - metabolism
α-Terpineol
β-Cyclodextrin
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Summary:The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin (βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its mechanism of action through docking study for a possible interaction with receptors. The αTPN-βCD complex was prepared and characterized through the thermogravimetry/derivate thermogravimetry (TG/DTG), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The model of chronic muscle pain was induced by two injections of pH 4.0 saline (20 μl) into the left gastrocnemius 5 days apart. After confirming hyperalgesia, male mice were treated with αTPN-βCD (25, 50 or 100 mg/kg; p.o.) or vehicle (saline 0.9%, p.o.) daily for 10 days. 1 h after the mechanical hyperalgesia, motor performance was evaluated. In addition, the systemic administration of naloxone and ondansetron tested the analgesic effect on the active opioid and serotonin receptors, respectively. The characterization tests indicated that αTPN was efficiently incorporated into βCD. The oral treatment with αTPN-βCD, at all doses tested, produced a significant (p 
ISSN:0009-2797
1872-7786
DOI:10.1016/j.cbi.2016.05.029