Correlation of serum sHLA‐G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion strategy?

Summary Patients with cystic echinococcosis (CE) can harbour cysts for years or even decades, apparently without effect of the immune system on the metacestode. Although several immune evasion mechanisms by echinococcal cysts have been described, it is unclear whether the human leucocyte antigen (HL...

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Bibliographic Details
Published in:Parasite immunology 2016-07, Vol.38 (7), p.414-418
Main Authors: Mariconti, M., Meroni, V., Badulli, C., Brunetti, E., Tinelli, C., De Silvestri, A., Tamarozzi, F., Genco, F., Casulli, A., Martinetti, M.
Format: Article
Language:English
Subjects:
Adult
Animals
Dendritic Cells - immunology
Dendritic Cells - parasitology
disease
Echinococcosis - blood
Echinococcosis - immunology
Echinococcosis - parasitology
Echinococcus - genetics
Echinococcus - growth & development
Echinococcus - immunology
Echinococcus spp
Enzyme-Linked Immunosorbent Assay
Female
HLA-G Antigens - blood
HLA-G Antigens - immunology
host species
human
Humans
hydatidosis
Immune Evasion
immune modulation
Immune Tolerance
immunological terms
Killer Cells, Natural - immunology
Killer Cells, Natural - parasitology
Male
Middle Aged
parasite
T-Lymphocytes - immunology
T-Lymphocytes - parasitology
tools and techniques
Young Adult
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Summary:Summary Patients with cystic echinococcosis (CE) can harbour cysts for years or even decades, apparently without effect of the immune system on the metacestode. Although several immune evasion mechanisms by echinococcal cysts have been described, it is unclear whether the human leucocyte antigen (HLA) system plays a role in the susceptibility or resistance to CE in humans. HLA‐G molecules are known to exert a suppressive action on dendritic cells maturation and on natural killer (NK) cells functions, therefore hampering T‐cell responses and NK cytolysis. HLA‐G plays an important role in immune tolerance, is involved in foetus and in allotransplant tolerance, and may be involved in tumoral and viral immune evasion. In this study, we assessed the presence and levels of soluble HLA‐G (sHLA‐G) in patients with CE using a commercial ELISA kit to determine whether host's HLA‐G may have a role in the course of human CE.
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12328