Effect of Repetitive Transcranial Magnetic Stimulation on Physical Function and Motor Signs in Parkinson's Disease: A Systematic Review and Meta-Analysis

Highlights • rTMS improves upper limb function in the short-term in people with PD. • rTMS improves walking performance and motor signs measured by UPDRS III in both the short- and long-terms in people with PD. • Effects of rTMS applied at M1 may be more prominent than SMA and DLFPC, and the treatme...

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Bibliographic Details
Published in:Brain stimulation 2016-07, Vol.9 (4), p.475-487
Main Authors: Chung, C.L, Mak, M.K.Y
Format: Article
Language:English
Subjects:
Humans
Meta-analysis
Neurology
Outcome Assessment (Health Care) - statistics & numerical data
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Repetitive transcranial magnetic stimulation
Systematic review
Transcranial Magnetic Stimulation - statistics & numerical data
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Summary:Highlights • rTMS improves upper limb function in the short-term in people with PD. • rTMS improves walking performance and motor signs measured by UPDRS III in both the short- and long-terms in people with PD. • Effects of rTMS applied at M1 may be more prominent than SMA and DLFPC, and the treatment effect of rTMS was associated with the total number of stimulation pulses and treatment sessions. Multiple sessions of rTMS produced a stronger effect on UPDRS III at short-term, and a greater number of stimulation pulses produced a stronger effect on UPDRS III at long-term. • There is a greater improvement in UPDRS III scores with rTMS when it was assessed during “off” medication state.
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2016.03.017