Promotion of Allograft Survival by CD4 super(+)CD25 super(+) Regulatory T Cells: Evidence for In Vivo Inhibition of Effector Cell Proliferation

Regulatory T cells preserve tolerance to peripheral self-Ags and may control the response to allogeneic tissues to promote transplantation tolerance. Although prior studies have demonstrated prolonged allograft survival in the presence of regulatory T cells (T-reg), data documenting the capacity of...

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Published in:The Journal of immunology (1950) 2004-06, Vol.172 (11), p.6539-6544
Main Authors: Lee IV, Major K, Moore, Daniel J, Jarrett, Beth P, Lian, Moh Moh, Deng, Shaoping, Huang, Xiaolun, Markmann, Joseph W, Chiaccio, Meredith, Barker, Clyde F, Caton, Andrew J, Markmann, James F
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Language:English
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Summary:Regulatory T cells preserve tolerance to peripheral self-Ags and may control the response to allogeneic tissues to promote transplantation tolerance. Although prior studies have demonstrated prolonged allograft survival in the presence of regulatory T cells (T-reg), data documenting the capacity of these cells to promote tolerance in immunocompetent transplant models are lacking, and the mechanism of suppression in vivo remains unclear. We used a TCR transgenic model of allograft rejection to characterize the in vivo activity of CD4 super(+)CD25 super(+) T-reg. We demonstrate that graft Ag-specific T-reg effectively intercede in the rejection response of naive T cells to established skin allografts. Furthermore, CFSE labeling demonstrates impaired proliferation of naive graft Ag-specific T cells in the draining lymph node in the presence of T- reg. These results confirm the efficacy of T-reg in promoting graft survival and suggest that their suppressive action is accomplished in part through inhibition of proliferation.
ISSN:0022-1767