Abdominal wall hernias—A local manifestation of systemically impaired quality of the extracellular matrix

Background Throughout life, inguinal hernia develops in approximately every fourth man, some of whom develop multiple hernias. If patients at risk of developing multiple hernias could be identified by a serologic biomarker, treatment might be able to be tailored and improved. Evidence suggests that...

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Published in:Surgery 2016-07, Vol.160 (1), p.220-227
Main Authors: Henriksen, Nadia A., MD, PhD, Mortensen, Joachim H., MSc, Lorentzen, Lea, MD, Ågren, Magnus S., DMSc, Bay-Jensen, Anne C., PhD, Jorgensen, Lars N., MD, DMSc, Karsdal, Morten A., PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Case-Control Studies
Cohort Studies
Collagen Type IV - physiology
Collagen Type V - physiology
Extracellular Matrix - physiology
Hernia, Ventral - blood
Hernia, Ventral - etiology
Hernia, Ventral - surgery
Herniorrhaphy
Humans
Male
Middle Aged
Surgery
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Summary:Background Throughout life, inguinal hernia develops in approximately every fourth man, some of whom develop multiple hernias. If patients at risk of developing multiple hernias could be identified by a serologic biomarker, treatment might be able to be tailored and improved. Evidence suggests that abdominal wall hernia formation is associated with altered collagen metabolism. The aim of this study was to evaluate biomarkers for type IV and V collagen turnover in patients with multiple hernias and control subjects without hernia. Methods Venous blood was collected from 88 men (mean age, 62 years) with a history of more than 3 hernia repairs and 86, age-matched men without hernias. Biomarkers for synthesis of collagen type IV (P4NP) and type V (P5CP) as well as breakdown (C4M and C5M) were measured in serum by validated, solid-phase, competitive assays. Collagen turnover was indicated by the ratio between the biomarker for synthesis and breakdown. Results Type IV collagen turnover was 1.4-fold increased in patients with multiple hernias compared to control subjects ( P  
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2016.02.011