Determinants of HIV-1 Load in Subjects with Early and Later HIV Infections, in a General-Population Cohort of Rakai, Uganda

Human immunodeficiency virus (HIV) type 1 RNA loads were determined for 256 subjects with early (incident) HIV infection and for 1293 subjects with later (prevalent) HIV infection, in a Ugandan cohort. Prevalent infections were classified as latent (0-1 symptoms) and midstage disease (⩾2 symptoms),...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-04, Vol.189 (7), p.1209-1215
Main Authors: Gray, Ronald H., Li, X., Wawer, Maria J., Serwadda, David, Sewankambo, Nelson K., Mangen, Fred Wabwire, Lutalo, Tom, Kiwanuka, Noah, Kigozi, Godfrey, Nalugoda, Fred, Meehan, Mary P., Robb, Merlin, Quinn, Thomas C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
AIDS
Biological and medical sciences
Cohort Studies
Female
Fundamental and applied biological sciences. Psychology
Herpes Simplex - virology
Herpesvirus 2, Human - growth & development
HIV
HIV 1
HIV infections
HIV Infections - complications
HIV Infections - virology
HIV-1 - growth & development
HIV/AIDS
Human herpesvirus 2
Human immunodeficiency virus 1
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Randomized Controlled Trials as Topic
RNA, Viral - blood
Sex Factors
Symptoms
Tuberculosis
Uganda
Ulcer - virology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Viremia
Virology
Viruses
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Summary:Human immunodeficiency virus (HIV) type 1 RNA loads were determined for 256 subjects with early (incident) HIV infection and for 1293 subjects with later (prevalent) HIV infection, in a Ugandan cohort. Prevalent infections were classified as latent (0-1 symptoms) and midstage disease (⩾2 symptoms), and deaths were ascribed to acquired immunodeficiency syndrome. Among subjects with incident HIV infection, HIV load did not differ by sex, but, among subjects with prevalent HIV infection, it was higher in males than in females. HIV load was highest in subjects (25-29 years old) with incident HIV infection but increased with age in subjects with prevalent HIV infection. Viremia was higher after serconversion than in latency and increased with more advanced disease. Viremia was increased with genital ulcer disease (GUD) in both subjects with incident infection and in those with prevalent infection, and with herpes simplex virus type 2 seropositivity in subjects with incident HIV infection. GUD was consistently associated with higher HIV loads in subjects with incident and those with prevalent HIV infection, suggesting that treatment of GUD might reduce HIV viremia.
ISSN:0022-1899
1537-6613
DOI:10.1086/382750