An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.

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Bibliographic Details
Published in:CrystEngComm 2016-01, Vol.18 (9), p.1486-1488
Main Authors: Zeidan, T. A., Trotta, J. T., Tilak, P. A., Oliveira, M. A., Chiarella, R. A., Foxman, B. M., Almarsson, Ö., Hickey, M. B.
Format: Article
Language:English
Subjects:
Crystal structure
Crystals
Drugs
Metabolites
Nucleation
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Description
Summary:A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.
ISSN:1466-8033
1466-8033
DOI:10.1039/C5CE02467F