Transdermal iontophoresis of flufenamic acid loaded PLGA nanoparticles

The objective of this study was to test in vitro a drug delivery system that combines nanoencapsulation and iontophoresis for the transdermal delivery of lipophilic model drug using poly(lactic-co-glycolic acid) (PLGA) as the carrier polymer. Negatively charged fluorescent nanoparticles loaded with...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmaceutical sciences 2016-06, Vol.89, p.154-162
Main Authors: Malinovskaja-Gomez, K., Labouta, H.I., Schneider, M., Hirvonen, J., Laaksonen, T.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Chemistry, Pharmaceutical - methods
Drug Delivery Systems - methods
Flufenamic Acid - administration & dosage
Flufenamic Acid - chemistry
Humans
Iontophoresis
Iontophoresis - methods
Lactic Acid - administration & dosage
Lactic Acid - chemistry
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanotechnology
NSAID delivery
Poly(lactic-co-glycolic acid) nanoparticles
Polyglycolic Acid - administration & dosage
Polyglycolic Acid - chemistry
Skin - metabolism
Skin Absorption - physiology
Skin permeation
Swine
Transdermal drug delivery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to test in vitro a drug delivery system that combines nanoencapsulation and iontophoresis for the transdermal delivery of lipophilic model drug using poly(lactic-co-glycolic acid) (PLGA) as the carrier polymer. Negatively charged fluorescent nanoparticles loaded with negatively charged flufenamic acid were prepared. The colloidal properties of the particles were stable under iontophoretic current (constant, pulsed and alternating) profiles and in contact with skin barrier. The release of the drug from the particles was not affected by iontophoresis and remained always limited (≈50%), leading to significantly lower transdermal fluxes across human epidermis and full thickness porcine skin compared to respective free drug formulation. From nanoparticles, pulsed current profile resulted in comparable or higher fluxes compared to constant current profile although fluorescence imaging was not able to confirm deeper distribution of nanoparticles in skin. Based on our results, there is no clear advantage with respect to drug permeation from nanoencapsulating flufenamic acid into PLGA nanoparticles compared to free drug formulation, either in passive or iontophoretic delivery regimens. However, pulsed current iontophoresis could be an effective alternative instead of traditional constant current iontophoresis to enhance transdermal permeation of drugs from nanoencapsulated formulations. [Display omitted]
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2016.04.034