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K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis
K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library,...
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| Published in: | Medical Oncology 2016-07, Vol.33 (7), p.61-61, Article 61 |
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| container_end_page | 61 |
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| container_start_page | 61 |
| container_title | Medical Oncology |
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| creator | Li, Tao Zheng, Yuanting Sun, Hong Zhuang, Rongyuan Liu, Jing Liu, Tianshu Cai, Weimin |
| description | K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library, Web of Science and Google Scholar were performed through December 2015 to identify publications exploring the association of K-Ras mutation with overall survival. Forty eligible studies involving 3427 patients with pancreatic cancer were included in the present meta-analysis. Our analysis showed a hazard ratio (HR) of negative association with survival of 1.61 [95 % confidence interval (CI) 1.36–1.90;
p
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| doi_str_mv | 10.1007/s12032-016-0777-1 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1792370137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1792370137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f29b018d83adea557be056f2bb05ee840381cfa22fa438eddde7c81250dde36b3</originalsourceid><addsrcrecordid>eNp1kdtqFTEYhYNYbK0-gDcS8Mab2Bx2dma8k-IJC4IoeBcyyT81dSazmz9j2Q_TdzWzp0oRvMpK8q2VwyLkmeCvBOfmDIXkSjIutowbY5h4QE6E1i0TSnx_WLXShnG95cfkMeIV51Jo2T4ix9JIqVvVnJDbT-yLQzrOxZU4JRqggD-omOgQr-cYaBenHe6pS4GWeZwyLRFxBlp9uzxdpglL9As1uvwT8uLc1TRIBelNLD_qLPkMbqF8lZBfU0dxjwXGw2KGXxFuVnaE4phLbthjxCfkqHcDwtO78ZR8e_f26_kHdvH5_cfzNxfMKyML62XbcdGERrkATmvTQX11L7uOa4Bmw1UjfO-k7N1GNRBCAOMbITWvSm07dUperrn1PdczYLFjRA_D4BJMM1phWqkMF8pU9MU_6NU053rfAyVku5FmWymxUj5PiBl6u8uxfs_eCm6X7uzana3d2aU7K6rn-V3y3I0Q_jr-lFUBuQJYt9Il5HtH_zf1N5E_qAc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791294276</pqid></control><display><type>article</type><title>K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis</title><source>Springer Link</source><creator>Li, Tao ; Zheng, Yuanting ; Sun, Hong ; Zhuang, Rongyuan ; Liu, Jing ; Liu, Tianshu ; Cai, Weimin</creator><creatorcontrib>Li, Tao ; Zheng, Yuanting ; Sun, Hong ; Zhuang, Rongyuan ; Liu, Jing ; Liu, Tianshu ; Cai, Weimin</creatorcontrib><description>K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library, Web of Science and Google Scholar were performed through December 2015 to identify publications exploring the association of K-Ras mutation with overall survival. Forty eligible studies involving 3427 patients with pancreatic cancer were included in the present meta-analysis. Our analysis showed a hazard ratio (HR) of negative association with survival of 1.61 [95 % confidence interval (CI) 1.36–1.90;
p
< 0.01] in K-Ras mutant pancreatic cancer patients. In subgroup analyses, K-Ras mutations detected in tumor tissues and in liquid biopsies had HRs of 1.37 (95 % CI 1.20–1.57;
p
< 0.01) and 3.16 (95 % CI 2.1–4.71;
p
< 0.01), respectively. In addition, the HR was higher when K-Ras mutations were detected in fresh frozen samples (HR = 2.01, 95 % CI 1.28–3.16,
p
= 0.002) than in formalin-fixed, paraffin-embedded (FFPE) samples (HR = 1.29, 95 % CI 1.12–1.49,
p
< 0.01). Though K-Ras alterations are more frequent among non-East Asian individuals than East Asian individuals, there were no significant differences in HRs of survival between the two ethnic subgroups. In conclusion, this meta-analysis suggests that K-Ras mutations are associated with a worse overall survival in pancreatic cancer patients, especially when mutations are detected in liquid biopsies or fresh frozen tumor tissue samples.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-016-0777-1</identifier><identifier>PMID: 27225938</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Biopsy - methods ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - mortality ; Carcinoma, Pancreatic Ductal - pathology ; DNA Mutational Analysis ; Hematology ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mutation ; Oncology ; Pancreatic cancer ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pathology ; Prognosis ; Proto-Oncogene Proteins p21(ras) - genetics ; Review Article</subject><ispartof>Medical Oncology, 2016-07, Vol.33 (7), p.61-61, Article 61</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f29b018d83adea557be056f2bb05ee840381cfa22fa438eddde7c81250dde36b3</citedby><cites>FETCH-LOGICAL-c372t-f29b018d83adea557be056f2bb05ee840381cfa22fa438eddde7c81250dde36b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,786,790,798,27955,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27225938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Zheng, Yuanting</creatorcontrib><creatorcontrib>Sun, Hong</creatorcontrib><creatorcontrib>Zhuang, Rongyuan</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Liu, Tianshu</creatorcontrib><creatorcontrib>Cai, Weimin</creatorcontrib><title>K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis</title><title>Medical Oncology</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library, Web of Science and Google Scholar were performed through December 2015 to identify publications exploring the association of K-Ras mutation with overall survival. Forty eligible studies involving 3427 patients with pancreatic cancer were included in the present meta-analysis. Our analysis showed a hazard ratio (HR) of negative association with survival of 1.61 [95 % confidence interval (CI) 1.36–1.90;
p
< 0.01] in K-Ras mutant pancreatic cancer patients. In subgroup analyses, K-Ras mutations detected in tumor tissues and in liquid biopsies had HRs of 1.37 (95 % CI 1.20–1.57;
p
< 0.01) and 3.16 (95 % CI 2.1–4.71;
p
< 0.01), respectively. In addition, the HR was higher when K-Ras mutations were detected in fresh frozen samples (HR = 2.01, 95 % CI 1.28–3.16,
p
= 0.002) than in formalin-fixed, paraffin-embedded (FFPE) samples (HR = 1.29, 95 % CI 1.12–1.49,
p
< 0.01). Though K-Ras alterations are more frequent among non-East Asian individuals than East Asian individuals, there were no significant differences in HRs of survival between the two ethnic subgroups. In conclusion, this meta-analysis suggests that K-Ras mutations are associated with a worse overall survival in pancreatic cancer patients, especially when mutations are detected in liquid biopsies or fresh frozen tumor tissue samples.</description><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biopsy - methods</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - mortality</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>DNA Mutational Analysis</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins p21(ras) - genetics</subject><subject>Review Article</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kdtqFTEYhYNYbK0-gDcS8Mab2Bx2dma8k-IJC4IoeBcyyT81dSazmz9j2Q_TdzWzp0oRvMpK8q2VwyLkmeCvBOfmDIXkSjIutowbY5h4QE6E1i0TSnx_WLXShnG95cfkMeIV51Jo2T4ix9JIqVvVnJDbT-yLQzrOxZU4JRqggD-omOgQr-cYaBenHe6pS4GWeZwyLRFxBlp9uzxdpglL9As1uvwT8uLc1TRIBelNLD_qLPkMbqF8lZBfU0dxjwXGw2KGXxFuVnaE4phLbthjxCfkqHcDwtO78ZR8e_f26_kHdvH5_cfzNxfMKyML62XbcdGERrkATmvTQX11L7uOa4Bmw1UjfO-k7N1GNRBCAOMbITWvSm07dUperrn1PdczYLFjRA_D4BJMM1phWqkMF8pU9MU_6NU053rfAyVku5FmWymxUj5PiBl6u8uxfs_eCm6X7uzana3d2aU7K6rn-V3y3I0Q_jr-lFUBuQJYt9Il5HtH_zf1N5E_qAc</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Li, Tao</creator><creator>Zheng, Yuanting</creator><creator>Sun, Hong</creator><creator>Zhuang, Rongyuan</creator><creator>Liu, Jing</creator><creator>Liu, Tianshu</creator><creator>Cai, Weimin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis</title><author>Li, Tao ; Zheng, Yuanting ; Sun, Hong ; Zhuang, Rongyuan ; Liu, Jing ; Liu, Tianshu ; Cai, Weimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f29b018d83adea557be056f2bb05ee840381cfa22fa438eddde7c81250dde36b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biopsy - methods</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - mortality</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>DNA Mutational Analysis</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins p21(ras) - genetics</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Zheng, Yuanting</creatorcontrib><creatorcontrib>Sun, Hong</creatorcontrib><creatorcontrib>Zhuang, Rongyuan</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Liu, Tianshu</creatorcontrib><creatorcontrib>Cai, Weimin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Tao</au><au>Zheng, Yuanting</au><au>Sun, Hong</au><au>Zhuang, Rongyuan</au><au>Liu, Jing</au><au>Liu, Tianshu</au><au>Cai, Weimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis</atitle><jtitle>Medical Oncology</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>33</volume><issue>7</issue><spage>61</spage><epage>61</epage><pages>61-61</pages><artnum>61</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>ObjectType-Review-4</notes><notes>content type line 23</notes><notes>ObjectType-Undefined-3</notes><abstract>K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library, Web of Science and Google Scholar were performed through December 2015 to identify publications exploring the association of K-Ras mutation with overall survival. Forty eligible studies involving 3427 patients with pancreatic cancer were included in the present meta-analysis. Our analysis showed a hazard ratio (HR) of negative association with survival of 1.61 [95 % confidence interval (CI) 1.36–1.90;
p
< 0.01] in K-Ras mutant pancreatic cancer patients. In subgroup analyses, K-Ras mutations detected in tumor tissues and in liquid biopsies had HRs of 1.37 (95 % CI 1.20–1.57;
p
< 0.01) and 3.16 (95 % CI 2.1–4.71;
p
< 0.01), respectively. In addition, the HR was higher when K-Ras mutations were detected in fresh frozen samples (HR = 2.01, 95 % CI 1.28–3.16,
p
= 0.002) than in formalin-fixed, paraffin-embedded (FFPE) samples (HR = 1.29, 95 % CI 1.12–1.49,
p
< 0.01). Though K-Ras alterations are more frequent among non-East Asian individuals than East Asian individuals, there were no significant differences in HRs of survival between the two ethnic subgroups. In conclusion, this meta-analysis suggests that K-Ras mutations are associated with a worse overall survival in pancreatic cancer patients, especially when mutations are detected in liquid biopsies or fresh frozen tumor tissue samples.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27225938</pmid><doi>10.1007/s12032-016-0777-1</doi><tpages>1</tpages></addata></record> |
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| subjects | Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biopsy - methods Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology DNA Mutational Analysis Hematology Humans Internal Medicine Medicine Medicine & Public Health Mutation Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pathology Prognosis Proto-Oncogene Proteins p21(ras) - genetics Review Article |
| title | K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis |
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