K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis

K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library,...

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Bibliographic Details
Published in:Medical Oncology 2016-07, Vol.33 (7), p.61-61, Article 61
Main Authors: Li, Tao, Zheng, Yuanting, Sun, Hong, Zhuang, Rongyuan, Liu, Jing, Liu, Tianshu, Cai, Weimin
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Biopsy - methods
Carcinoma, Pancreatic Ductal - genetics
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - pathology
DNA Mutational Analysis
Hematology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Mutation
Oncology
Pancreatic cancer
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pathology
Prognosis
Proto-Oncogene Proteins p21(ras) - genetics
Review Article
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Summary:K-Ras gene mutations have been found in most pancreatic cancers; however, conflicting data on the prognostic value of K-Ras mutations in pancreatic cancer have been published. We conducted a meta-analysis to assess its prognostic significance. Literature searches of PubMed, EMBASE, Cochrane Library, Web of Science and Google Scholar were performed through December 2015 to identify publications exploring the association of K-Ras mutation with overall survival. Forty eligible studies involving 3427 patients with pancreatic cancer were included in the present meta-analysis. Our analysis showed a hazard ratio (HR) of negative association with survival of 1.61 [95 % confidence interval (CI) 1.36–1.90; p  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-016-0777-1