CCL2 gene polymorphism is associated with post-transplant diabetes mellitus

Post-transplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation, especially in recipients treated with calcineurin inhibitors. Previous studies suggest that chronic inflammation and chemokines play an important role in the pathogenesis of diabetes. Single-nucleoti...

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Bibliographic Details
Published in:International immunopharmacology 2016-03, Vol.32, p.62-65
Main Authors: Dabrowska-Zamojcin, Ewa, Romanowski, Maciej, Dziedziejko, Violetta, Maciejewska-Karlowska, Agnieszka, Sawczuk, Marek, Safranow, Krzysztof, Domanski, Leszek, Pawlik, Andrzej
Format: Article
Language:English
Subjects:
Calcineurin Inhibitors - therapeutic use
CCL2
CCL5
Chemokine CCL2 - genetics
Chemokine CCL5 - genetics
Cyclosporine - therapeutic use
Diabetes Mellitus - etiology
Diabetes Mellitus - genetics
Female
Graft
Humans
Immunosuppressive Agents - therapeutic use
Kaplan-Meier Estimate
Kidney
Kidney Transplantation
Male
Polymorphism
Polymorphism, Single Nucleotide
Post-transplant diabetes mellitus
Postoperative Complications - genetics
Tacrolimus - therapeutic use
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Summary:Post-transplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation, especially in recipients treated with calcineurin inhibitors. Previous studies suggest that chronic inflammation and chemokines play an important role in the pathogenesis of diabetes. Single-nucleotide polymorphisms (SNPs) can increase or decrease transcriptional activity and can change the production of chemokines. The aim of this study was to examine the association between CCL2 and CCL5 gene polymorphisms and the development of post-transplant diabetes mellitus. The study included 315 patients who received kidney transplants and were treated with calcineurin inhibitors. Patients were divided into two subgroups: with PTDM (n=43) and without PTDM (n=272). An additive model of univariate Cox regression analysis showed that the hazard of PTDM development was significantly positively associated with the number of CCL2 rs1024611 G alleles (HR 1.65; 95%CI 1.08–2.53; p=0.021). Multivariate Cox regression analysis, taking into the account the recipient's sex, age and BMI, as well as the number of G alleles of the CCL2 rs1024611 polymorphism, revealed that this polymorphism is an independent risk factor for post-transplant diabetes. The results of our study suggest an association between the CCL2 gene rs1024611 G allele and PTDM in patients treated with tacrolimus or cyclosporine. •PTDM is an important metabolic complication after solid organ transplantation.•The therapy with calcineurin inhibitors (tacrolimus and cyclosporine) is associated with PTDM occurrence.•CCL2 plays an important role in the regulation of insulin secretion.•CCL2 gene rs1024611 G allele may be associated with the PTDM.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2016.01.011