Evaluation of Ag containing hydroxyapatite coatings to the Candida albicans infection

In this research work, the synthesis of Ag doped hydroxyapatite coatings for dental or orthopedic implants was performed. The main goal was to determine the influence of Ag content on the roughness and antimicrobial performance of the prepared thin films. The films were deposited on Ti6Al4V alloy by...

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Bibliographic Details
Published in:Journal of microbiological methods 2016-06, Vol.125, p.12-18
Main Authors: Ciuca, S., Badea, M., Pozna, E., Pana, I., Kiss, A., Floroian, L., Semenescu, A., Cotrut, C.M., Moga, M., Vladescu, A.
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biomedical applications
Candida albicans
Candida albicans - drug effects
Candidiasis - microbiology
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Dental Implants
Durapatite - chemistry
Durapatite - pharmacology
Electromagnetic Fields
Magnetron sputtering
Prostheses and Implants
Roughness
Silver
Silver - analysis
Silver - chemistry
Silver - pharmacology
Surface Properties
Titanium - chemistry
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Summary:In this research work, the synthesis of Ag doped hydroxyapatite coatings for dental or orthopedic implants was performed. The main goal was to determine the influence of Ag content on the roughness and antimicrobial performance of the prepared thin films. The films were deposited on Ti6Al4V alloy by means of RF magnetron sputtering. Those coatings were characterized by X-ray diffraction (XRD) and 3D surface profilometry. The antifungal activity after 1 and 7days of culture was evaluated in the presence of Candida albicans (ATCC — 10231). The increase of Ag content increased roughness and reduced the antifungal activity. The results showed that the Ag doped hydroxyapatite coatings can be a potential solution for the improvement of the antifungal activities of Ti based alloy. [Display omitted] •Ag doped hydroxyapatite coatings were prepared by RF magnetron sputtering.•The Ag addition does not affect the formation of the hydroxyapatite structure.•Ag addition into hydroxyapatite increased roughness.•The antifungal activity for the coating was 2.1% Ag.
ISSN:0167-7012
1872-8359
DOI:10.1016/j.mimet.2016.03.016