A double‐blind randomised controlled trial on the effect of dehydroepiandrosterone on ovarian reserve markers, ovarian response and number of oocytes in anticipated normal ovarian responders

Objective To assess the effect of dehydroepiandrosterone (DHEA) on antral follicle count (AFC), ovarian response to a standard low dose of gonadotrophin stimulation and number of oocytes in anticipated normal responders undergoing in vitro fertilisation (IVF). Design Randomised, double‐blind, placeb...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2016-06, Vol.123 (7), p.1097-1105
Main Authors: Yeung, TWY, Chai, J, Li, RHW, Lee, VCY, Ho, PC, Ng, EHY
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone - metabolism
Clinical outcomes
Dehydroepiandrosterone
Dehydroepiandrosterone - administration & dosage
DHEA
Double-Blind Method
Double-blind studies
Drug Administration Schedule
Drug therapy
Evidence-based medicine
Female
Fertility Agents, Female - administration & dosage
Fertilization
Fertilization in Vitro
Follicle Stimulating Hormone - metabolism
Follicle-stimulating hormone
Gynecology
Humans
in vitro fertilisation
In vitro fertilization
Infertility
Infertility, Female - drug therapy
Menotropins - administration & dosage
normal ovarian responders
Oocytes
Oocytes - drug effects
Ovarian Follicle - drug effects
Ovarian Reserve - drug effects
Ovulation Induction - methods
Pituitary (anterior)
Steroids
Testosterone
Testosterone - metabolism
Treatment Outcome
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Summary:Objective To assess the effect of dehydroepiandrosterone (DHEA) on antral follicle count (AFC), ovarian response to a standard low dose of gonadotrophin stimulation and number of oocytes in anticipated normal responders undergoing in vitro fertilisation (IVF). Design Randomised, double‐blind, placebo‐controlled study. Setting Tertiary reproductive unit. Population Seventy‐two subfertile women with AFC of 5–15 scheduled for IVF. Methods Eligible women were randomised into the DHEA group (n = 36), who received DHEA (GNC®, 25 mg three times a day), or the placebo group (n = 36), who received placebo, starting from 12 weeks before the scheduled IVF treatment according to a computer‐generated randomisation list. Monthly assessment of AFC, serum anti‐Mullerian hormone (AMH) and follicle‐stimulating hormone (FSH) levels, ovarian response to a standard dose of gonadotrophin stimulation at week 8 and the number of oocytes obtained were compared. Main outcome measures The primary outcome was AFC after 12 weeks of DHEA or placebo. Results DHEA for 12 weeks prior to IVF treatment in anticipated normal responders leads to significantly higher serum and follicular DHEA‐S and testosterone relative to placebo. However, no significant differences in AFC, AMH and FSH, ovarian response to standard‐dose ovarian stimulation and IVF cycle outcomes can be detected. Conclusion No significant differences in AFC, ovarian response to a standard low dose of gonadotrophin stimulation and number of oocytes obtained were detected in anticipated normal responders receiving 12 weeks of DHEA prior to IVF treatment relative to placebo. Tweetable No difference in ovarian response markers in normal responders receiving 12 weeks of DHEA. Tweetable No difference in ovarian response markers in normal responders receiving 12 weeks of DHEA.
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.13808