Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium–Pilocarpine Model of Status Epilepticus in Rats

It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium–pilocarpine model of status epilepticus (SE) in rats. The aim of the present study was to investigate the effect of 5-HT depletion by short-term a...

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Published in:Cellular and molecular neurobiology 2016-05, Vol.36 (4), p.513-519
Main Authors: García-García, Luis, Shiha, Ahmed Anis, Bascuñana, Pablo, de Cristóbal, Javier, Fernández de la Rosa, Rubén, Delgado, Mercedes, Pozo, Miguel A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Brief Communication
Cell Biology
Disease Models, Animal
Fenclonine
Gliosis - pathology
Hippocampus - diagnostic imaging
Hippocampus - metabolism
Hippocampus - pathology
Lithium
Magnetic Resonance Imaging
Male
Nerve Degeneration - diagnostic imaging
Nerve Degeneration - metabolism
Nerve Degeneration - pathology
Neurobiology
Neurosciences
Pilocarpine
Positron-Emission Tomography
Rats, Sprague-Dawley
Serotonin - deficiency
Status Epilepticus - diagnostic imaging
Status Epilepticus - metabolism
Status Epilepticus - pathology
Time Factors
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Summary:It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium–pilocarpine model of status epilepticus (SE) in rats. The aim of the present study was to investigate the effect of 5-HT depletion by short-term administration of p -chlorophenylalanine (PCPA), a specific tryptophan hydroxylase inhibitor, on the brain hypometabolism and neurodegeneration induced in the acute phase of this SE model. Our results show that 5-HT depletion did modify neither the brain basal metabolic activity nor the lithium–pilocarpine-induced hypometabolism when evaluated 3 days after the insult. In addition, hippocampal neurodegeneration and astrogliosis triggered by lithium–pilocarpine were not exacerbated by PCPA treatment. These findings point out that in the early latent phase of epileptogenesis, non-5-HT-mediated actions may contribute, at least in some extent, to the neuroprotective effects of fluoxetine in this model of SE.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-015-0240-4