The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

Cytokines related to tumor necrosis factor (TNF) provide a communication network essential for coordinating multiple cell types into an effective host defense system against pathogens and malignant cells. The pathways controlled by the TNF superfamily differentiate both innate and adaptive immune ce...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2016-05, Vol.44 (5), p.1005-1019
Main Authors: Ward-Kavanagh, Lindsay K., Lin, Wai Wai, Šedý, John R., Ware, Carl F.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Antigens
Autoimmune diseases
Autoimmune Diseases - immunology
Cancer
Celiac disease
Chromosome Deletion
Chromosome Disorders - genetics
Chromosomes
Chromosomes, Human, Pair 1 - genetics
Clinical trials
Communication
Disease
Gangrene
Homeostasis
Humans
Immunity, Innate
Immunotherapy - methods
Immunotherapy - trends
Inflammatory bowel disease
Ligands
Lupus
Lymphocyte Activation
Lymphocytes
Neoplasms - immunology
Neurogenesis - genetics
Receptor Cross-Talk
Receptors, Tumor Necrosis Factor - metabolism
Signal Transduction
T cell receptors
T-Lymphocytes - immunology
Tumor necrosis factor-TNF
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Summary:Cytokines related to tumor necrosis factor (TNF) provide a communication network essential for coordinating multiple cell types into an effective host defense system against pathogens and malignant cells. The pathways controlled by the TNF superfamily differentiate both innate and adaptive immune cells and modulate stromal cells into microenvironments conducive to host defenses. Members of the TNF receptor superfamily activate diverse cellular functions from the production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention on the subset of TNF superfamily receptors encoded in the immune response locus in chromosomal region 1p36. Recent studies have revealed that these receptors use diverse mechanisms to either co-stimulate or restrict immune responses. Translation of the fundamental mechanisms of TNF superfamily is leading to the design of therapeutics that can alter pathogenic processes in several autoimmune diseases or promote immunity to tumors. A deeper understanding of the network of cellular and molecular pathways initiated by the TNF superfamily of cytokines is emerging from fundamental research and human clinical trials. Selective modulation of these cytokines could achieve the goal of limiting cancer without autoimmune disease as a restricting consequence.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2016.04.019