Pleiotropic effect of thyroid hormones on gene expression in fish as exemplified from the blue bream Ballerus ballerus (Cyprinidae): Results of transcriptomic analysis

A pronounced pleiotropic effect of thyroid hormones on the regulation of gene expression in fish in postembryogenesis was demonstrated for the first time using larvae and juveniles of the blue bream Ballerus ballerus as an example. Genome-wide transcriptome sequencing (RNA-seq) identified 1212 diffe...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2016-03, Vol.467 (1), p.124-127
Main Authors: Rastorguev, S. M., Nedoluzhko, A. V., Levina, M. A., Prokhorchuk, E. B., Skryabin, K. G., Levin, B. A.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Brain - growth & development
Brain - metabolism
Cyprinidae - growth & development
Cyprinidae - metabolism
Fish
Fish Proteins - metabolism
Gene expression
Gene Expression - physiology
Gene Expression Profiling
Gene Ontology
Hormones
Larva
Life Sciences
Liver - growth & development
Liver - metabolism
Thyroid gland
Thyroid Hormones - administration & dosage
Thyroid Hormones - metabolism
Transcriptome - physiology
Triiodothyronine - administration & dosage
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Summary:A pronounced pleiotropic effect of thyroid hormones on the regulation of gene expression in fish in postembryogenesis was demonstrated for the first time using larvae and juveniles of the blue bream Ballerus ballerus as an example. Genome-wide transcriptome sequencing (RNA-seq) identified 1212 differentially expressed genes in the brain and liver of fish kept in triiodothyronine solution (0.25 ng/mL). Our data show that the regulation of gene expression by thyroid hormones is widespread in nature: it involves not only the structural genes but also the regulatory genes. A significant number of genes under the control of thyroid hormones are involved in the determination of morphological traits.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672916020137