Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction

Highlights • Chronic stress causes hippocampal-dependent memory deficit. • Exercise improves memory in chronically stressed mice. • Chronic stress reduces hippocampal AMPK activity, BDNF, and neurogenesis. • Exercise enhances hippocampal AMPK activity in chronically stressed mice. • AMPK is required...

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Bibliographic Details
Published in:Neuroscience 2016-06, Vol.324, p.271-285
Main Authors: Kim, D.-M, Leem, Y.-H
Format: Article
Language:English
Subjects:
Aminoimidazole Carboxamide - analogs & derivatives
Aminoimidazole Carboxamide - pharmacology
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
BDNF
Brain-Derived Neurotrophic Factor - metabolism
Cells, Cultured
Chronic Disease
chronic restraint stress
Disease Models, Animal
Dose-Response Relationship, Drug
Exercise Therapy
Hippocampus - drug effects
Hippocampus - physiopathology
learning and memory
Male
Maze Learning - physiology
Memory Disorders - etiology
Memory Disorders - physiopathology
Memory Disorders - therapy
Mice, Inbred C57BL
Neurogenesis - physiology
Neurology
Nootropic Agents - pharmacology
Restraint, Physical
Ribonucleotides - pharmacology
Running - physiology
Running - psychology
Stress, Psychological - complications
Stress, Psychological - physiopathology
Stress, Psychological - therapy
treadmill running
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Summary:Highlights • Chronic stress causes hippocampal-dependent memory deficit. • Exercise improves memory in chronically stressed mice. • Chronic stress reduces hippocampal AMPK activity, BDNF, and neurogenesis. • Exercise enhances hippocampal AMPK activity in chronically stressed mice. • AMPK is required for exercise-exerted memory and neurogenesis enhancement.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.03.019