Influence of population diversity on neurovirulence potential of plaque purified L-Zagreb variants

Highlights • Neurovirulence basis of L-Zagreb vaccine was investigated. • Six different L-Zagreb variants were isolated and characterized. • No genetic markers of neurovirulence could be identified. • Distinctive heterogeneity profiles were obtained for poorly neuroattenuated variants.

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Bibliographic Details
Published in:Vaccine 2016-04, Vol.34 (20), p.2383-2389
Main Authors: Ivancic-Jelecki, Jelena, Forcic, Dubravko, Jagusic, Maja, Kosutic-Gulija, Tanja, Mazuran, Renata, Lang Balija, Maja, Isakov, Ofer, Shomron, Noam
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell culture
Cercopithecus aethiops
Consensus Sequence
Defective Viruses - pathogenicity
Genomes
Immunology
L-Zagreb
Meningitis
Mumps
Mumps Vaccine
Mumps virus
Mumps virus - genetics
Mumps virus - isolation & purification
Mumps virus - pathogenicity
Mutation
Population
Proteins
Rat-based neurovirulence test
Rats
Rats, Inbred Lew
RNA polymerase
RNA, Viral - genetics
Sequence Analysis, RNA
Vaccines
Vaccines, Attenuated
Vero Cells
Viral Plaque Assay
Virulence
Virus population diversity
Virus variants
Viruses
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Description
Summary:Highlights • Neurovirulence basis of L-Zagreb vaccine was investigated. • Six different L-Zagreb variants were isolated and characterized. • No genetic markers of neurovirulence could be identified. • Distinctive heterogeneity profiles were obtained for poorly neuroattenuated variants.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.03.033