Anti-inflammatory Prenylated Flavonoids from Helminthostachys zeylanica

Two new [neougonins A (1) and B (2)] and nine known prenylated flavonoids were isolated from the whole plants of Helminthostachys zeylanica. The structures of the new isolates were elucidated by extensive NMR techniques, including one and two dimensional (1D)- and (2D)-NMR experiments, as well as co...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin 2016/05/01, Vol.64(5), pp.497-501
Main Authors:	Su, Li-Hua, Li, Yan-Ping, Li, Hong-Mei, Dai, Wei-Feng, Liu, Dan, Cao, Lang, Li, Rong-Tao
Format:	Article
Language:	eng ; jpn
Subjects:	Animals anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Dose-Response Relationship, Drug Ferns - chemistry Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Helminthostachys zeylanica Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Molecular Structure neougonin A neougonin B Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Ophioglossaceae prenylated flavonoid Prenylation Structure-Activity Relationship
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Summary:	Two new [neougonins A (1) and B (2)] and nine known prenylated flavonoids were isolated from the whole plants of Helminthostachys zeylanica. The structures of the new isolates were elucidated by extensive NMR techniques, including one and two dimensional (1D)- and (2D)-NMR experiments, as well as comparison with spectroscopic data of known analogous compounds. Moreover, compound 1 inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 3.32 µM.
ISSN:	0009-2363 1347-5223