Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women

Among Canadian women of reproductive age, 5% and 20% have serum vitamin B-12 concentrations indicative of deficiency (271 nmol/L), and no women had elevated tHcy (>13 μmol/L). Maternal dietary vitamin B-12 intake during pregnancy was either weakly associated or not associated with maternal and co...

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Bibliographic Details
Published in:The Journal of nutrition 2016-05, Vol.146 (5), p.1035-1042
Main Authors: Visentin, Carly E, Masih, Shannon P, Plumptre, Lesley, Schroder, Theresa H, Sohn, Kyoung-Jin, Ly, Anna, Lausman, Andrea Y, Berger, Howard, Croxford, Ruth, Lamers, Yvonne, Kim, Young-In, O'Connor, Deborah L
Format: Article
Language:English
Subjects:
Adult
Canada - epidemiology
Diet
Dietary Supplements
DNA Methylation
Female
Fetal Blood - metabolism
Fetus
Folic Acid - blood
Homocysteine - blood
Humans
Infant, Newborn
Methylmalonic Acid - blood
Polymorphism, Genetic
Pregnancy
Pregnancy Complications - epidemiology
Prevalence
Prospective Studies
Vitamin B 12 - administration & dosage
Vitamin B 12 - blood
Vitamin B 12 Deficiency - epidemiology
Vitamin B Complex - administration & dosage
Vitamin B Complex - blood
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Summary:Among Canadian women of reproductive age, 5% and 20% have serum vitamin B-12 concentrations indicative of deficiency (271 nmol/L), and no women had elevated tHcy (>13 μmol/L). Maternal dietary vitamin B-12 intake during pregnancy was either weakly associated or not associated with maternal and cord blood vitamin B-12 (r(2) = 0.17-0.24, P < 0.0008), tHcy (P = NS) and MMA (r(2) = 0.05-0.11, P < 0.001). Fetal genetic polymorphisms were not associated with cord blood concentrations of vitamin B-12 and its biomarkers. Deficient and marginal serum vitamin B-12 concentrations are prevalent in Canadian pregnant women with the use of traditional cutoffs, despite supplement use. Given the growing interest among women to adhere to a vegetarian diet that may be lower in vitamin B-12, and vitamin B-12's importance in pregnancy, the functional ramifications of these observations need to be elucidated. This trial was registered at clinicaltrials.gov as NCT02244684.
ISSN:0022-3166
1541-6100
DOI:10.3945/jn.115.226845