A new micro-contact imprinted l-cysteine sensor based on sol–gel decorated graphite/multiwalled carbon nanotubes/gold nanoparticles composite modified sandpaper electrode

•Fabrication of a MIP-based electrochemical sandpaper electrode sensor.•Micro-contact imprinting at graphite/MWCNTs/AuNPs/sol–gel composite modified sandpaper support.•Ultra-trace analysis of l-Cys in real samples without any cross-reactivity and false-positives.•A practical sensor for monitoring l-...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2015-06, Vol.212, p.155-164
Main Authors: Prasad, Bhim Bali, Singh, Ragini
Format: Article
Language:English
Subjects:
Differential pulse anodic stripping voltammetry
Electrodes
Gold
Modified sandpaper electrode
Molecularly imprinted polymer
Multi wall carbon nanotubes
Nanoparticles
Nanostructure
Real sample analysis
Sandpaper
Sensors
Sol gel process
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Summary:•Fabrication of a MIP-based electrochemical sandpaper electrode sensor.•Micro-contact imprinting at graphite/MWCNTs/AuNPs/sol–gel composite modified sandpaper support.•Ultra-trace analysis of l-Cys in real samples without any cross-reactivity and false-positives.•A practical sensor for monitoring l-Cys deficiency in HIV-patients. A new ultrasensing sandpaper electrode was fabricated using micro-contact imprinting technique for the detection of several diseases manifested at acute level depletion of l-cysteine. The concerted effect of molecularly imprinted polymer@graphite/multiwalled carbon nanotubes/gold nanoparticles/sol–gel composite led to the growth of a nanometer thin film coating on the surface of sandpaper electrode. Herein, the redox electron relay was channelized in between imprinted nanocomposite and aluminum stripe attached at the modified surface. Determination of the analyte (l-cysteine) could simply be performed by measuring differential pulse anodic stripping voltammetric signal of potassium ferricyanide used as an external probe. The limits of detection [0.26–0.30ngmL−1 (3σRSD≤2.5%)] obtained were free from any cross-reactivity and false-positive complications in aqueous, blood serum, and pharmaceutical samples. The proposed sensor can be used as a practical sensor for monitoring cysteine deficiency, particularly with HIV-infected patients.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2015.01.119