Gd-EOB enhanced MRI T1-weighted 3D-GRE with and without elevated flip angle modulation for threshold-based liver volume segmentation

Background Despite novel software solutions, liver volume segmentation is still a time-consuming procedure and often requires further manual optimization. With the high signal intensity of the liver parenchyma in Gd-EOB enhanced magnetic resonance imaging (MRI), liver volume segmentation may be impr...

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Bibliographic Details
Published in:Acta radiologica (1987) 2015-12, Vol.56 (12), p.1419-1427
Main Authors: Grieser, Christian, Denecke, Timm, Rothe, Jan-Holger, Geisel, Dominik, Stelter, Lars, Cannon Walter, Thula, Seehofer, Daniel, Steffen, Ingo G
Format: Article
Language:English
Subjects:
Contrast Media
Conversion
Deviation
Female
Gadolinium DTPA
Humans
Image Enhancement
Imaging, Three-Dimensional
Liver
Liver - pathology
Liver Neoplasms - pathology
Magnetic Resonance Imaging
Male
Manuals
Middle Aged
Optimization
Organ Size
Reproducibility of Results
Retrospective Studies
Segmentation
Sensitivity and Specificity
Three dimensional
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Summary:Background Despite novel software solutions, liver volume segmentation is still a time-consuming procedure and often requires further manual optimization. With the high signal intensity of the liver parenchyma in Gd-EOB enhanced magnetic resonance imaging (MRI), liver volume segmentation may be improved. Purpose To evaluate the practicability of threshold-based segmentation of the liver volume using Gd-EOB-enhanced MRI including a customized three-dimensional (3D) sequence. Material and Methods A total of 20 patients examined with Gd-EOB MRI (hepatobiliary phase T1-weighted (T1W) 3D sequence [VIBE]; flip angle [FA], 10° and 30°) were enrolled in this retrospective study. The datasets were independently processed by two blinded observers (O1 and O2) in two ways: manual (man) and threshold-based (thresh; study method) segmentation of the liver each followed by an optimization step (man+opt and thresh+opt; man+opt [FA10°] served as reference method). Resulting liver volumes and segmentation times were compared. A liver conversion factor was calculated in percent, describing the non-hepatocellular fraction of the total liver volume, i.e. bile ducts and vessels. Results Thresh+opt (FA10°) was significantly faster compared to the reference method leading to a median volume overestimation of 4%/8% (P 
ISSN:0284-1851
1600-0455
DOI:10.1177/0284185114558975