Relationship of long noncoding RNA and viruses

Long noncoding (lnc)RNAs comprise a diverse group of transcripts including large intervening noncoding (linc)RNAs, natural antisense transcripts (NATs) and intronic lncRNAs. The functions and mechanisms of more than 200 lncRNAs have been studied in vitro and the results suggest that lncRNAs may be m...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2016-04, Vol.107 (4), p.150-154
Main Authors: Ding, Yao-zhong, Zhang, Zhong-wang, Liu, Ya-li, Shi, Chong-xu, Zhang, Jie, Zhang, Yong-guang
Format: Article
Language:English
Subjects:
Adenovirus
Adenoviruses, Human - physiology
Animals
Cytomegalovirus
Epstein–Barr virus
Humans
Introns
Long noncoding RNA
Mice
Murine cytomegalovirus
Muromegalovirus - physiology
RNA, Long Noncoding - genetics
Theiler's encephalomyelitis virus
Theiler's virus
Theilovirus - physiology
Virus Replication
Viruses
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Summary:Long noncoding (lnc)RNAs comprise a diverse group of transcripts including large intervening noncoding (linc)RNAs, natural antisense transcripts (NATs) and intronic lncRNAs. The functions and mechanisms of more than 200 lncRNAs have been studied in vitro and the results suggest that lncRNAs may be molecular markers of prognosis in cancer patients. Some lncRNAs can promote virus replication and allow escape from cytosolic surveillance to suppress antiviral immunity. For example, lncRNA can cause persistent infection by Theiler's virus, and microRNA (miR)-27a/b is important for efficient murine cytomegalovirus (MCMV) replication. The available evidence suggests that lncRNAs may be potential targets of novel antiviral drugs. •Elaborating the relationship of LncRNAs with viruses,such as the lncRNA and Epstein–Barr virus (EBV) and lncRNA and Cytomegaloviruses
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2016.01.007