Factors that impact health-related quality of life in neuromyelitis optica spectrum disorder: anxiety, disability, fatigue and depression

Abstract Aims Neuromyelitis optica spectrum disorder (NMOSD) is associated with reduced health-related quality of life (HRQOL). This study aimed to investigate factors that impact HRQOL in NMOSD. Methods A series of questionnaires were completed by 73 patients to assess the relationships between HRQ...

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Bibliographic Details
Published in:Journal of neuroimmunology 2016-04, Vol.293, p.54-58
Main Authors: Shi, Ziyan, Chen, Hongxi, Lian, Zhiyun, Liu, Ju, Feng, Huiru, Zhou, Hongyu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allergy and Immunology
Anxiety
Anxiety - etiology
Depression
Depression - etiology
Disability Evaluation
Disabled Persons
Fatigue
Fatigue - etiology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurology
Neuromyelitis optica
Neuromyelitis Optica - complications
Neuromyelitis Optica - psychology
Psychiatric Status Rating Scales
Quality of life
Sleep Wake Disorders - etiology
Statistics as Topic
Surveys and Questionnaires
Young Adult
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Summary:Abstract Aims Neuromyelitis optica spectrum disorder (NMOSD) is associated with reduced health-related quality of life (HRQOL). This study aimed to investigate factors that impact HRQOL in NMOSD. Methods A series of questionnaires were completed by 73 patients to assess the relationships between HRQOL and fatigue, depression, anxiety and sleep disorder. We also evaluated the contributions of clinical characteristics to HRQOL. Correlation and regression analysis were conducted to identify factors that negatively impact HRQOL in NMOSD. Results Pearson's correlation analysis showed that reduced HRQOL was strongly correlated with anxiety (r =-0.77, P = 0.000), fatigue (r =-0.75, P = 0.000) and depression (r =-0.73, P = 0.000); and moderately correlated with disability (r =-0.53, P = 0.000) and sleep disorder (r =-0.59, P = 0.000). Stepwise regression analysis further revealed that anxiety was the best predictor of both the global and physical composite scores of HRQOL, followed by disability, fatigue and depression (global composite, r2 = 0.76, P = 0.000; physical composite, r2 = 0.71, P = 0.000). Depression, fatigue and anxiety were the main predictors of the mental health composite score of HRQOL (r2 = 0.69, P = 0.000). Other factors did not have an effect on HRQOL. Conclusions This study revealed factors that impact HRQOL in NMOSD and provided the first demonstration that anxiety, disability, fatigue and depression are independent predictors of poor HRQOL in NMOSD.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2016.02.011