Changed Serum Cytokine Profile in Mice in Response to Streptococcus A Culture

Comparative analysis of serum cytokine profiles of CBA mice was carried out 1, 5, 24, and 48 h after intraperitoneal injection of killed culture of different streptococcus A types. The production of cytokines in response to different streptococcus types varied. The highest level was recorded in resp...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-05, Vol.159 (1), p.66-69
Main Authors: Danilova, T. A., Adzhieva, A. A., Danilina, G. A., Lunin, V. G., Grabko, V. I., Minko, A. G.
Format: Article
Language:English
Subjects:
Analysis
Animals
Antigens
Antigens, Bacterial - immunology
Bacterial Outer Membrane Proteins - immunology
Biomedical and Life Sciences
Biomedicine
Carrier Proteins - immunology
Cell Biology
Cytokines
Cytokines - blood
Epitopes - immunology
Granulocyte-Macrophage Colony-Stimulating Factor - blood
Granulocyte-Macrophage Colony-Stimulating Factor - secretion
Health aspects
Infection
Inflammation
Injections, Intraperitoneal
Interferon-gamma - blood
Interferon-gamma - secretion
Interleukins - blood
Interleukins - secretion
Internal Medicine
Laboratory Medicine
Male
Mice
Mice, Inbred CBA
Molecular Mimicry
Myocardium - immunology
Pathology
Serogroup
Streptococcus
Streptococcus pyogenes - classification
Streptococcus pyogenes - immunology
Th1 Cells - immunology
Th1 Cells - secretion
Th2 Cells - immunology
Th2 Cells - secretion
Time Factors
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - secretion
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Summary:Comparative analysis of serum cytokine profiles of CBA mice was carried out 1, 5, 24, and 48 h after intraperitoneal injection of killed culture of different streptococcus A types. The production of cytokines in response to different streptococcus types varied. The highest level was recorded in response to types 1M and 3T+M, more often detected in invasive streptococcal infection. The highest levels of IL-2 were recorded in response to 1M (47-fold increase in comparison with the control) and 3T+M streptococcus types (more than 10-fold increase). Injections of these types also led to an increase of IFN-γ level (15.6 and 11.3 times, respectively). The level of TNF-α increased less (3.6 times in response to 3T+M and 2.6 times in response to 1M type). The levels of IL-5, IL-10, and IL-12 increased 2-3-fold. Injections of 1T and 5M types led to just a 2-fold increase of cytokine levels. These data indicated induction of the immune response trend by mainly Th1 or mixed Th1/Th2 pattern in response to group A streptococcus antigens.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2891-z