Pilot Study Exploring Lung Allograft Surfactant Protein A (SP‐A) Expression in Association With Lung Transplant Outcome

Primary graft failure and chronic lung allograft dysfunction (CLAD) limit lung transplant long–term outcomes. Various lung diseases have been correlated with surfactant protein (SP) expression and polymorphisms. We sought to investigate the role of SP expression in lung allografts prior to implantat...

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Bibliographic Details
Published in:American journal of transplantation 2013-10, Vol.13 (10), p.2722-2729
Main Authors: D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M., Keshavjee, S.
Format: Article
Language:English
Subjects:
Adult
Aged
Allografts
Biological and medical sciences
Bronchoalveolar Lavage Fluid
Cytokines - genetics
Female
Follow-Up Studies
Graft Rejection - diagnosis
Graft Rejection - genetics
Graft Rejection - mortality
Humans
Innate immunity
Lung Diseases - surgery
Lung Transplantation
Lungs
Male
Medical sciences
Middle Aged
Pilot Projects
Polymerase Chain Reaction
polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Prognosis
Prospective Studies
Proteins
Pulmonary Surfactant-Associated Protein A - genetics
Pulmonary Surfactant-Associated Protein D - genetics
Retrospective Studies
RNA, Messenger - genetics
surfactant protein A
Surfactants
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Rate
Transplants & implants
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Summary:Primary graft failure and chronic lung allograft dysfunction (CLAD) limit lung transplant long–term outcomes. Various lung diseases have been correlated with surfactant protein (SP) expression and polymorphisms. We sought to investigate the role of SP expression in lung allografts prior to implantation, in relation to posttransplant outcomes. The expression of SP‐(A, B, C, D) mRNA was assayed in 42 allografts. Posttransplant assessments include pulmonary function tests, bronchoscopy, broncho‐alveolar lavage fluid (BALF) and biopsies to determine allograft rejection. BALF was assayed for SP‐A, SP‐D in addition to cytokines IL‐8, IL‐12 and IL‐2. The diagnosis of CLAD was evaluated 6 months after transplantation. Lung allografts with low SP‐A mRNA expression prior to implantation reduced survival (Log‐rank p 
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12407