Individual and combined effects of deoxynivalenol and α-zearalenol on cell proliferation and steroidogenesis of granulosa cells in cattle

Highlights • Deoxynivalenol and zearalenone are mycotoxins produced by Fusarium species. • Granulosa cells were used to test the effects of deoxynivalenol and α-zearalenol. • Deoxynivalenol and α-zearalenol were tested alone and in combination. • Deoxynivalenol and α-zearalenol had effects on in vit...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-11, Vol.40 (3), p.722-728
Main Authors: Pizzo, Fabiola, Caloni, Francesca, Schutz, Luis F, Totty, Morgan L, Spicer, Leon J
Format: Article
Language:English
Subjects:
Animals
Cattle
Cell Count
Cell Proliferation - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Emergency
Estradiol
Female
Fusarium
Fusarium mycotoxins
Granulosa Cells - cytology
Granulosa Cells - drug effects
Granulosa Cells - metabolism
Ovary function
Progesterone
Steroids - metabolism
Trichothecenes - administration & dosage
Trichothecenes - pharmacology
Zeranol - administration & dosage
Zeranol - analogs & derivatives
Zeranol - pharmacology
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Summary:Highlights • Deoxynivalenol and zearalenone are mycotoxins produced by Fusarium species. • Granulosa cells were used to test the effects of deoxynivalenol and α-zearalenol. • Deoxynivalenol and α-zearalenol were tested alone and in combination. • Deoxynivalenol and α-zearalenol had effects on in vitro granulosa cells function. • Further studies are needed to better understand their effects on bovine species.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.08.025