Anti-oxidant profiles and markers of oxidative stress in preterm neonates

Background: Preterm birth is associated with an increased oxidant burden which places these infants at a higher risk of injury. Aims: This prospective study aimed to assess levels of antioxidants and a marker of oxidative stress in preterm neonates. Objectives: (i) To compare levels of anti-oxidants...

Full description

Saved in:
Bibliographic Details
Published in:Paediatrics and international child health 2016-04, Vol.36 (2), p.134-140
Main Authors: Abdel Ghany, Eman Abdel Ghany, Alsharany, Walaa, Ali, Aliaa Adel, Youness, Eman Refaat, Hussein, Jihan Seid
Format: Article
Language:English
Subjects:
Antioxidants
Antioxidants - metabolism
Biomarkers - blood
Chromatography, High Pressure Liquid
Dietary Supplements
Female
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - blood
Male
Malondialdehyde
NICU
Oxidative Stress
Preterm neonates
Prospective Studies
Total antioxidant status
Vitamin A
Vitamin E
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Preterm birth is associated with an increased oxidant burden which places these infants at a higher risk of injury. Aims: This prospective study aimed to assess levels of antioxidants and a marker of oxidative stress in preterm neonates. Objectives: (i) To compare levels of anti-oxidants [vitamin A, vitamin E, catalase, total anti-oxidant status (TAS)] as well as malondialdehyde level (MDA) (a marker of lipid peroxidation) between preterm and full-term neonates; (ii) to determine changes in the values of measured vitamins at birth and at discharge among preterm neonates; and (iii) to compare levels of anti-oxidants with MDA levels in relation to complications of prematurity and outcome. Methods: The study was undertaken in 100 preterm neonates and 100 full-term neonates as a control group. MDA was estimated by a thiobarbituric acid-reactive technique; TAS was determined using a Randox assay kit; catalase activity was measured spectrophotometrically and vitamin A and E levels were estimated by high performance liquid chromatography. Results: The plasma levels of vitamin A, vitamin E, TAS and catalase were significantly lower in the preterm than in the full-term group (P 
ISSN:2046-9047
2046-9055
DOI:10.1179/2046905515Y.0000000017