The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients

Abstract The prognostic value of phosphatase and tensin homolog (PTEN) negativity in breast cancer has been evaluated by many studies but remains controversial. We conducted a meta-analysis to assess the association of PTEN negativity with overall survival and disease-free survival. Thirty-two studi...

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Published in:Critical reviews in oncology/hematology 2016-05, Vol.101, p.40-49
Main Authors: Yang, Zu-Yao, Yu, Yuan-Yuan, Yuan, Jin-Qiu, Shen, Wei-Xi, Zheng, Da-Yong, Chen, Jin-Zhang, Mao, Chen, Tang, Jin-Ling
Format: Article
Language:English
Subjects:
breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Disease-Free Survival
Hematology, Oncology and Palliative Medicine
Humans
meta-analysis
overall survival
phosphatase and tensin homolog
Phosphoprotein Phosphatases - metabolism
Prognosis
systematic review
Tensins - metabolism
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Summary:Abstract The prognostic value of phosphatase and tensin homolog (PTEN) negativity in breast cancer has been evaluated by many studies but remains controversial. We conducted a meta-analysis to assess the association of PTEN negativity with overall survival and disease-free survival. Thirty-two studies with 4393 patients were identified. PTEN negativity was significantly associated with unfavorable overall survival in breast cancer (hazard ratio = 1.89, 95% confidence interval 1.58–2.26), with low heterogeneity among the studies ( I2 = 25%, P = 0.160) and no evidence for publication bias. Meta-analysis of multivariate hazard ratios and sensitivity analyses did not materially change the results. The data on disease-free survival was heterogeneous ( I2 = 61.9%, P
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2016.01.013