Posterior Fossa Intra-axial Tumors in Adults

Abstract Background The posterior fossa is the site of many types of tumors, and brain metastases are the most common malignancies in that location among adults. Other brain tumors, such as ependymomas, medulloblastomas and juvenile pilocytic astrocytomas, mostly occur during childhood and are relat...

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Bibliographic Details
Published in:World neurosurgery 2016-04, Vol.88, p.140-145
Main Authors: Grossman, Rachel, MD, Ram, Zvi, MD
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Brain tumors
Ependymomas
Evidence-Based Medicine
Female
Gliomas
Humans
Infratentorial Neoplasms - diagnosis
Infratentorial Neoplasms - metabolism
Infratentorial Neoplasms - therapy
Lymphomas
Male
Medulloblastomas
Neurosurgery
Outcome
Pilocytic astrocytomas
Posterior fossa
Treatment Outcome
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Summary:Abstract Background The posterior fossa is the site of many types of tumors, and brain metastases are the most common malignancies in that location among adults. Other brain tumors, such as ependymomas, medulloblastomas and juvenile pilocytic astrocytomas, mostly occur during childhood and are relatively rare in the adult population. The majority of primary malignant brain tumors, such as gliomas and lymphomas, tend to be located in the supratentorial compartment. Methods In this review we summarized the current data including prognostic factors and therapeutic management and molecular data of patients with intra-axial posterior fossa tumors in adults including ependymomas, medulloblastomas pilocytic astrocytomas in the "posterior fossa in adults. Results We present the literature on intra-axial posterior fossa tumors in adults that relies mainly on limited retrospective clinical studies and employing a wide range of treatment approaches that were usually based on therapies developed specifically for children or for supratentorial brain tumors Conclusions The clinical course and surgical outcome of adult patients with intra-axial brain tumors in the posterior fossa is summarized in this review. The prognostic factors and therapeutic management of patients with these tumors are controversial due to their rarity, their heterogeneity and the lack of sufficient data in the literature.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2015.12.066