Tumor characteristics and therapy of elderly patients with breast cancer

Introduction Elderly breast cancer patients aged ≥75 years are underrepresented in most studies. Therefore, data on cancer characteristics, adjuvant treatment and survival in elderly patients are missing. Patients and methods In this retrospective study, we compared tumor characteristics and adjuvan...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2016-05, Vol.142 (5), p.1109-1116
Main Authors: Grumpelt, A.-M., Ignatov, A., Tchaikovski, S. N., Burger, E., Costa, S.-D., Eggemann, H.
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cancer Research
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - therapy
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - mortality
Carcinoma, Lobular - pathology
Carcinoma, Lobular - therapy
Chemotherapy, Adjuvant
Combined Modality Therapy
Female
Follow-Up Studies
Hematology
Humans
Immunoenzyme Techniques
Internal Medicine
Medical treatment
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Older people
Oncology
Original Article – Clinical Oncology
Prognosis
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Retrospective Studies
Sentinel Lymph Node Biopsy
Survival analysis
Survival Rate
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Summary:Introduction Elderly breast cancer patients aged ≥75 years are underrepresented in most studies. Therefore, data on cancer characteristics, adjuvant treatment and survival in elderly patients are missing. Patients and methods In this retrospective study, we compared tumor characteristics and adjuvant therapy in 973 women with invasive, non-metastasized breast cancer aged ≥75 years with 3377 younger postmenopausal patients (50–74 years old). Time dynamics of tumor characteristics were investigated, comparing two observation periods between the years 2000–2004 versus 2005–2008. Results Compared to younger women, older patients were more often treated with mastectomy and less likely to receive adjuvant treatment. Although the overall survival rate increased over the observation period in both age groups, the older study group was characterized by shorter disease-free survival. Additionally, we observed an increase in about 1.65 years in the age at diagnosis as well as an increasing rate of breast-conserving surgery and sentinel lymph node biopsy for the whole study population between 2000 and 2008. Furthermore, we found a reduction in the proportion of estrogen receptor-positive tumors in the younger women and a decrease in G3-tumors in both age groups over the study time. Conclusion The older group’s reduced disease-free survival could be explained by the tumor characteristics and differences in the adjuvant treatment. Remarkably, elderly women are more likely to be overtreated surgically while being undertreated in terms of adjuvant therapy.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-015-2111-2